Compositions for the diagnosis and treatment of Chediak-Higashi

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 6, 4353201, 536 235, C12N 1585

Patent

active

059522232

ABSTRACT:
The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the differentiation and/or function of intracellular vesicles. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian bg gene, a gene that, when mutated, is responsible for the human Chediak-Higashi syndrome.

REFERENCES:
Rieger, R. et al. (eds.), Glossary of Genetics and Cytogenetics, Springer-Verlag, New York, 1976, pp. 17-18.
Barrat, F.J. et al., Am. J. Hum. Genet., 59:625-32, Sep. 1996.
Ramsay, M., Nature Genetics, 14:242-245, Nov. 1996.
Nagle, D.L. et al., Nature Genetics, 14:307-311, Nov. 1996.
Barbosa, M. et al., 1996, "Identification of the Homologous Beige and Chediak-Higashi Syndrome Genes", Nature 382:262-265.
Cockett, M. et al., 1991, "The Use of Engineered E1A Genes to Transactivate the hCMV-MIE Promoter in Permanent CHO Cell Lines", Nucleic Acids Research 19:319-325.
Duronio, R., 1992, "Comparative Analysis of the .beta. Transducin Family with Identification of Several New Members Including PWP1, a Nonessential Gene of Saccharomyces cerevisiae that is Divergently Transcribed from NMT1", Proteins: Structure, Function, and Genetics 13:41-56.
Jenkins, N. et al., 1991, "Nidogen/Enactin (Nid) Maps to the Proximal End of Mouse Chromosome 13 Linked to Beige (bg) and Identifies a New Region of Homology between Mouse and Human Chromosomes", Genomics 9:401-403.
Johnstone and Thorpe, 1987, "Production of Antibodies" in Immunochemistry in Practice, Johnstone and Thorpe, eds. Blackwell Scientific Publications, Oxford, U.K., pp. 30-47.
Perou, C. et al., 1996, "Identification of the Murine Beige Gene by YAC Complementation and Positional Cloning", Nature Genetics 13:303-308.
Perou and Kaplan, 1993, "Complementation Analysis of Chediak-Higashi Syndrome: The Same Gene may be Responsible for the Defect in All Patients and Species", Somatic Cell and Molecular Genetics 19:459-468.
Perou and Kaplan, 1993, "Chediak-Higashi Syndrome is Not Due to a Defect in Microtubule-Based Lysosomal Mobility", J. of Cell Science 106:99-107.
Schlegel and Rechsteiner, 1975, "Microinjection of Thymidine Kinase and Bovine Serum Albumin into Mammalian Cells by Fusion with Red Blood Cells", Cell 5:371-379.
van der Voorn and Ploegh, 1992, "The WD-40 Repeat", FEBS Letters 307:131-134.
Wang, D.S. et al., 1994, "Binding of pH Domains of .beta.-Adrenergic Receptor Kinase and .beta.-Spectrin to WD40/.beta.-Transducin Repeat Containing Regions of the .beta.-Subunit of Trimeric G-Proteins", Biochem. Biophys. Res. Comm. 203:29-35.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compositions for the diagnosis and treatment of Chediak-Higashi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions for the diagnosis and treatment of Chediak-Higashi , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions for the diagnosis and treatment of Chediak-Higashi will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1509398

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.