Compositions for the delivery of negatively charged molecules

Details Compositions for the delivery of negatively charged molecules Compositions for the delivery of negatively charged molecules

2005-04-14

2009-06-30

O'Sullivan, Peter G (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

C552S506000

Reexamination Certificate

active

07553830

ABSTRACT:
This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAS, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.

REFERENCES:
patent: 5958901 (1999-09-01), Dwyer et al.

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