Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1988-07-27
1991-07-23
Robinson, Douglas W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
514824, 5482622, 5482624, C07D25100, C07D24912, C07D24916, C07D40300, C07D48700, A61K 3153, A61K 3141
Patent
active
050345281
ABSTRACT:
The invention provides pharmaceutical compositions comprising hypolipidemically active derivatives of 1,2,4-triazolidine-3,5-diones, 1,3,5-triazabicyclo[3.1.0]hexane-2,4-diones, and 1,3,5-triazine-2,4(1H,3H)-diones in a pharmaceutically acceptable carrier for treating hyperlipidemia in mammals, particularly humans.
REFERENCES:
patent: 3133933 (1964-05-01), Ruschig et al.
patent: 3184470 (1965-05-01), Ruschig et al.
patent: 3634445 (1968-08-01), Zschocke et al.
patent: 3663564 (1972-05-01), Jacobson et al.
patent: 4088767 (1978-05-01), Shigematsu et al.
patent: 4433085 (1984-02-01), Rottmaier et al.
CA100:87234j, Rodina et al. (1984).
Chapman, John, J., Master's Thesis, "The Reaction of Carbene Precursors with Electron Deficient cis-Azo Compounds," catalogued in James E. Shepard Memorial Library (date uncertain).
Mitchell, John A., Master's Thesis, "Synthesis of 6-Carbethoxy-3-Aryl-1,3,5-Triazine-2,4 (1H, 3H)--Diones From Bicyclic Diaziridines," catalogued in James E. Shepard Memorial Library (approximately 1986).
Izydore, R. A., "1,2-Addition Reaction of Ethyl Diazoacetate and 4-Phenyl-1,2,4-Triazoline-3,5-Dione," JACS, 97(19), 5611-12 (1975).
Presentation at the Eleventh Annual MBRS Symposium, 1983, abstract enclosed.
Presentation at the 175th ACS National Meeting, 1978, paper ORGN 114, abstract enclosed.
CA95(25):220015k, Zh. Org. Khim., 17(9), 2021-2 (1981).
CA83(21):177770r, J. Am. Chem. Soc., 97(19), 5611-12 (1975).
CA100(12):87234j, Khim. Geterotsikl. Soedin., (12), 1694-5 (1983).
CA97(19):162927n, Pharmazie, 37(5), 355-6, 1982.
CA85(21):160141e, BG Appl. 73/120377, 25 Oct. 1973.
CA82(5):26145u, BG Appl. 21,720, 25 Oct. 1972.
CA103(19):156291b, Biochem. Med., 34(1), 60-9 (1985).
CA103(17):137521k, Biochem. Med., 34(1), 70-82 (1985).
CA99(11):84849p, J. Protozool., 30(1), 36-40 (1983).
CA98(3):13472d, Int. J. Parasitol., 12(5), 377-82 (1982).
CA96(1):2855p, Aust. J. Exp. Biol. Med. Sci., 59(4), 477-90 (1981).
CA71(25):120792x, Collect. Czech. Chem. Commun, 34(10), 3189-90 (1969).
CA71(19):87946a, Biochem. Biophys, Acta, 185, 186-97 (1969).
CA68(17):76682y, Biochem. Biophys. Acta, 155(2), 623-5 (1968).
CA107(19):173715t, Jpn. J. Pharmacol., 45(1), 37-43, 1987.
CA100(15):114452n, Adv. Exp. Med. Biol., 165A(Purine Metab. Man-4, Pt. A), 175-8 (1984).
CA97(25):213834q, Proc. Soc. Exp. Biol. Med., 170(4), 476-85 (1982).
CA90(19):145664n, Life Sci., 23(22), 2239-44 (1978).
CA106(23):192090f, Biomed. Chromatogr., 1(3), 109-18 (1986).
CA103(19):15629b, Biochem. Med., 34(1), 60-9 (1985).
CA102(23):199725t, Am. J. Physiol., 248(4, Pt. 2), F574-F584 (1985).
CA102(3):20981y, Mol. Mekh. Izmen. Nasledstvennoi Inf. Mikroorg.,63-79, edited by: Maurinya, Kh. A. Latv. Gos. Univ.: Riga, USSR.
CA102(1):3167v, Molekul. Mekhanizmy Izmeneniya Nasledstven. Inf. u Mikroorganizmov, Riga 62-79, From: Ref. Zh., Fiz.-Khim. Biol. (1983).
Biotekhnol. 1984, Abstr. No. 10B10.
CA101(25):227294b, Mol. Biochem. Parasitol., 12(2), 153-71 (1984).
CA101(21):186788v, Biochem. Pharmacol., 33(15), 2383-95 (1984).
CA101(19):163579p, Nippon Yakurigaku Zasshi, 84(3), 293-301 (1984).
CA100(21):172694d, Nihon Univ. J. Med., 25(6), 369-79 (1983).
CA99(21):173966s, Mie Igaku, 26(4), 483-92 (1983).
CA77(1):128n, Biochem. Pharmacol., 21(5), 607-17 (1972).
CA69(5):17856f, Collect. Czech. Chem. Commun., 33(6), 1778-87 (1968).
CA68(5):20678j, Biochem. Biophys. Acta, 149(1), 314-16, (1967).
CA107(7):54712e, Biomed. Biochem. Acta, 46(5), 307-15, (1987).
CA107(7):54712e, Biomed. Biochem. Acta, 46(5), 307-15, (1987).
CA107(7):54712e, Biomed. Biochim. Acta, 46(5), 307-15 (1987).
CA86(25):183914u, Z. Naturforsch., B: Anorg. Chem., Org. Chem., 32B(4), 447-52 (1977).
CA67(22):103902h, Chem. Commun., (14), 693-4 (1967).
CA105(23):208822p, Tetrahedron, 42(2), 747-51 (1986).
CA103(11):87874e (1985).
CA94(11):76452k, Jpn. J. Pharmacol., 30(6), 829-40 (1980).
CA94(1):233u, Adv. Exp. Med. Biol., 122A(Purine Metab. Man-3: Clin. Ther. Aspects), 269-76 (1980).
CA93(15):148764t, Rev. Rhum. Mal. Osteo-Articulaires, 47(6), 393-8 (1980).
CA93(7):65635a, Ann. Trop. Med. Parasitol., 74(2), 109-14 (1980).
CA93(5):46609d, Nucl. Acid Chem., Col. 1, 93-5, Edited by: Towsend, Leroy, B.; Tipson, R. Sturart, Wiley: New York, N.Y. (1978).
CA91(19):151263t, Clin. Exp. Hypertens., 1(4), 487-508 (1979).
CA91(7):49181c, J. Pharm. Sci., 68(5), 651-2 (1979).
CA90(1):6364b, Nucleic Acid Chem., vol. 1, 93-5. Edited by: Towsend, Leroy B.; Tipson, R. Sturart. Wiley: New York, N.Y.
CA91(23):193262x, J. Org. Chem., 44(22), 3769-78, (1979).
CA105(23):208822p, Tetrahedron, 42(2), 747-51, (1986).
CA88(3):22848b, J. Chem. Res. (S), (10), 239, (1977).
CA104(11):88351q, Tetrahedron Lett., 26(26), 3173-6, (1985).
CA83(21):177770r, J. Am. Chem. Soc., 97(19), 5611-12, (1975).
CA91(23):193262x, J. Org. Chem., 44(22), 3769-78, (1979).
CA91(8):66743e, Acta Crystallogr., Sect. B, B35(6), 1509-12, (1979).
CA90(18):141759z, Ozone/Chlorine Dioxide Oxide, Prod. Org. Mater., Proc. Conf., Meeting Date 1976, 284-90. Edited by: Rice, Rip G.; Cotruvo, Joseph A., Ozone Press Int.: Cleveland, Ohio.
CA89(16):135042y, Jt. Conf. Sens. Environ. Pollut., (Conf. Proc.), 4th. Meeting Date 1977, 507-10/ACS: Washington, D.C.
Hall Iris H.
Izydore Robert A.
Henley III Raymond J.
North Carolina Central University
Robinson Douglas W.
The University of North Carolina at Chapel Hill
LandOfFree
Compositions for the control of hyperlipidemia does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions for the control of hyperlipidemia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions for the control of hyperlipidemia will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-433472