Compositions for repairing bone

Details Compositions for repairing bone Compositions for repairing bone

2005-03-02

2010-11-09

Davis, Ruth A (Department: 1651)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

C424S422000, C424S489000, C424S490000, C424S492000, C435S325000

Reexamination Certificate

active

07829105

ABSTRACT:
This invention relates to an improved method of preparing an implantable gel or paste for placement between injured bones or placement in bony voids to induce regeneration, and the compositions produced thereby. Specifically, mineral, ceramic, or processed bone particles are coated with a high molecular weight polymer capable of forming a viscous gel when reconstituted with water, saline, autologous blood, sera, or other medically acceptable solution. This high molecular weight polymer coating material may be a natural or synthetic polymeric material, producing a wettable gel upon exposure to water, saline, or another solution. In storage, the composition will be granular and dry but easily wetted. In use, the material is reconstituted to a viscous malleable paste by the simple addition of water or other medically acceptable solution without the need for aggressive mixing. The paste may be delivered by syringe or manually deposited yet will be resistant to lavage or to displacement by gravity induced flow.

REFERENCES:
patent: 4191747 (1980-03-01), Scheicher
patent: 4352884 (1982-10-01), Nakashima et al.
patent: 4938763 (1990-07-01), Dunn et al.
patent: 5035896 (1991-07-01), Apfel et al.
patent: 5324519 (1994-06-01), Dunn et al.
patent: 5650108 (1997-07-01), Nies et al.
patent: 5702716 (1997-12-01), Dunn et al.
patent: 5744153 (1998-04-01), Yewey et al.
patent: 5990194 (1999-11-01), Dunn et al.
patent: 6030635 (2000-02-01), Gertzman et al.
patent: 6311690 (2001-11-01), Jefferies
patent: 6344496 (2002-02-01), Niederauer et al.
patent: 6773714 (2004-08-01), Dunn et al.
patent: 7122057 (2006-10-01), Beam et al.
patent: 2001/0014831 (2001-08-01), Scarborough
patent: 2001/0016703 (2001-08-01), Wironen et al.
patent: 2001/0037091 (2001-11-01), Wironen et al.
patent: 2002/0018796 (2002-02-01), Wironen
patent: 2002/0076429 (2002-06-01), Wironen et al.
patent: 2002/0098222 (2002-07-01), Wironen et al.
patent: 2003/0180262 (2003-09-01), Wironen et al.
patent: 41 26 800 (1993-02-01), None
patent: 0 041 614 (1981-12-01), None
patent: 0 581 387 (1994-02-01), None
patent: WO 90/01955 (1990-03-01), None
patent: WO 91/02811 (1991-03-01), None
patent: WO 03/090717 (2003-11-01), None
patent: WO 2005/084725 (2005-09-01), None
Department of Health & Human Services, Food and Drug Administration, 510(k) No. K062459 Summary and Letter (2007).
Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Public Health Statement, Barium CAS#: 7440-39-3:1-6 (2005).
Divisional U.S. Appl. No. 11/776,997, Methods of Repairing Bone, filed Jul. 12, 2007.
Divisional U.S. Appl. No. 11/777,001, Methods for Preparing Compositions for Repairing Bone, filed Jul. 12, 2007.
Examination Report dated Mar. 1, 2007, in European Patent Application No. 05724174.7.
Graphs with Gel Forming Quality of Gelatin, Great Lakes Gelatin, Greyslake, IL, 2007.
Response to Examination Report dated Mar. 1, 2007, in European Patent Application No. 05724174.7, filed with the European Patent Office on Aug. 13, 2007.
Sabokbar et al.,J. Bone Joint Surg.79-B:129-134 (1997).
Wimhurst et al.,J. Bone Joint Surg., 83-B:588-592 (2001).
Examination Report dated Oct. 31, 2007, in European Patent Application No. 05724174.7.
International Search Report for Application No. PCT/US2005/006579 dated Aug. 26, 2005.
English Language Derwent Abstract for DE 41 26 800.
English Language Derwent Abstract for EP 0 041 614.

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