Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
1999-03-12
2001-02-06
Page, Thurman K. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C514S844000, C514S846000, C514S847000, C514S848000, C424S045000, C424S047000, C424S059000, C424S060000, C424S070100, C424S070110
Reexamination Certificate
active
06183761
ABSTRACT:
TECHNICAL FIELD
The present invention relates to composition for preventing or treating skin disorders using vitamin B3 compounds and polycyclic compounds. The present invention also relates to methods for regulating skin condition.
BACKGROUND OF THE INVENTION
Many personal care products currently available to consumers are directed primarily to improving the health and/or physical appearance of the skin. Among these skin care products, many are directed to delaying, minimizing or even eliminating skin wrinkling and other histological changes typically associated with the aging of skin or environmental damage to human skin. Other types of products are useful for imparting moisturization to dry skin, providing photoprotection for skin exposed to sunlight, and bringing about desired control of pigmentation, especially lightening of darkened or hyperpigmented skin.
Skin is subject to insults by many extrinsic and intrinsic factors. Extrinsic factors include ultraviolet radiation (e.g., from sun exposure), environmental pollution, wind, heat or infrared radiation (IR), low humidity, harsh surfactants, abrasives, and the like. Intrinsic factors include chronological again and other biochemical changes from within the skin. Whether extrinsic or intrinsic, these factors result in visible signs of skin aging and environmental damage, such as wrinkling and other forms of roughness (including increased pore size, flaking and skin lines), and other histological changes associated with skin aging or damage. To many people, skin wrinkles are a reminder of the disappearance of youth. As a result, the elimination of wrinkles has become a booming business in youth-conscious societies. Treatments range from cosmetic creams and moisturizers to various forms of cosmetic surgery.
Extrinsic or intrinsic factors may result in the thinning and general degradation of the skin. For example, as the skin naturally ages, there is a reduction in the cells and blood vessels that supply the skin. There is also a flattening of the dermal-epidermal junction which results in weaker mechanical resistance of this junction. See, for example, Oikarinen, “The Aging of Skin: Chronoaging Versus Photoaging,”
Photodermatol. Photoimmunol. Photomed.,
vol. 7, pp. 3-4, 1990, which is incorporated by reference herein in its entirety.
It has now been found that topical compositions containing a vitamin B
3
compound and select polycyclic compounds provide benefits in regulating skin condition previously unrecognized in the art of which the present inventors are aware. For example, such compositions regulate the signs of skin aging, especially visible and/or tactile discontinuities in skin texture associated with aged skin, including fine lines and wrinkles.
It is therefore an object of the present invention to provide topical compositions for prophylactically and/or therapeutically regulating mammalian skin condition (especially of human skin, more especially facial skin), containing a vitamin B
3
compound and a polycyclic compound.
It is another object of the present invention to provide topical compositions for prophylactically and/or therapeutically regulating signs of mammalian skin aging containing a vitamin B
3
compound and a polycyclic compound.
It is another object of the present invention to provide topical compositions for prophylactically and/or therapeutically regulating visible and/or tactile discontinuities in mammalian skin texture, including fine lines, wrinkles, enlarged pores, roughness, dryness and other skin texture discontinuities associated with aged skin, containing a vitamin B
3
compound and a polycyclic compound.
The present invention also relates to methods of providing such regulation using the subject compositions.
These and other objects of this invention will become apparent in light of the following disclosure.
SUMMARY OF THE INVENTION
The present invention relates to topical compositions comprising:
(a) a safe and effective amount of a vitamin B3 compound;
(b) a safe and effective amount of a polycyclic compound selected from the group consisting of:
(i) flavanones selected from the group consisting of unsubstituted flavanones, mono-substituted flavanones, and mixtures thereof;
(ii) chalcones selected from the group consisting of unsubstituted chalcones, mono-substituted chalcones, di-substituted chalcones, tri-substituted chalcones, and mixtures thereof;
(iii) flavones selected from the group consisting of unsubstituted flavones, mono-substituted flavones, di-substituted flavones, and mixtures thereof;
(iv) one or more isoflavones;
(v) coumarins selected form the group consisting of unsubstituted coumarins, mono-substituted coumarins, di-substituted coumarins, and mixtures thereof;
(vi) chromones selected from the group consisting of unsubstituted chromones, mono-substituted chromones, di-substituted chromones, and mixtures thereof;
(vii) one or more dicoumarols;
(viii) one or more chromanones;
(ix) one or more chromanols; and
(x) sterols selected from the group consisting of stigmasterol, stigmastanol, brassicasterol, campesterol, and mixtures thereof;
(xi) triterpenoids selected from the group consisting of betulinic acid, boswellic acid, and mixtures thereof; and
(x) mixtures thereof;
and
(c) a dermatologically acceptable carrier for the vitamin B3 compound and the polycyclic compound.
The present invention further relates to methods for treating and regulating skin condition using the topical compositions.
DETAILED DESCRIPTION OF THE INVENTION
All percentages and ratios used herein are by weight of the total composition and all measurements made are at 25° C., unless otherwise designated.
The compositions of the present invention can comprise, consist essentially of, or consist of, the essential as well as optional ingredients and components described herein. As used herein, “consisting essentially of” means that the composition or component may include additional ingredients, but only if the additional ingredients do not materially alter the basic and novel characteristics of the claimed compositions or methods.
All publications cited herein are hereby incorporated by reference in their entirety.
The term “topical application”, as used herein, means to apply or spread the compositions of the present invention onto the surface of the skin.
The term “dermatologically-acceptable,” as used herein, means that the compositions or components thereof so described are suitable for use in contact with human skin without undue toxicity, incompatibility, instability, allergic response, and the like.
The term “safe and effective amount” as used herein means an amount of a compound or composition sufficient to significantly induce a positive benefit, preferably a positive skin appearance or feel benefit, including independently the benefits disclosed herein, but low enough to avoid serious side effects, i.e., to provide a reasonable benefit to risk ratio, within the scope of sound judgment of the skilled artisan.
The compositions of the present invention are useful for topical application and for regulating skin condition, including visible and/or tactile discontinuities in skin (especially the skin surface; such discontinuities are generally undesired). Such discontinuities may be induced or caused by internal and/or external factors, and include the signs of skin aging described herein. “Regulating skin condition” includes prophylactically regulating and/or therapeutically regulating skin condition, including visible and/or tactile discontinuities in skin such as, but not limited to, regulating visible and/or tactile discontinuities in the texture of skin, reducing post-inflammatory hyperpigmentation, regulating non-melanin discoloration of skin, regulating moisturization and barrier properties of skin, regulating epidermal differentiation of skin, regulating exfoliation of skin, thickening of skin to reduce skin atrophy, regulating the elasticity of skin, reducing oily skin, regulating cellulite in skin, regulating pruritus in skin, promoting wound healing in skin, protecting skin from enviro
Bissett Donald Lynn
Oblong John Erich
Howard S.
Little Darryl C.
Matthews Armina E.
Page Thurman K.
The Procter & Gamble & Company
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