Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2006-11-07
2006-11-07
Schnizer, Richard (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C424S450000, C435S458000, C435S461000
Reexamination Certificate
active
07132404
ABSTRACT:
The present invention provides a composition of matter for introducing an exogenous nucleic acid molecule into a target cell, comprising a liposome, a ligand polymeric scaffold, wherein the ligand can bind to a cell surface receptor or molecule. The invention also provides methods for introducing an exogenous nucleic acid molecule into a target cell using the composition of matter.
REFERENCES:
patent: 5128257 (1992-07-01), Baer
patent: 5593972 (1997-01-01), Weiner et al.
patent: 5605890 (1997-02-01), Agrawal et al.
patent: 5736392 (1998-04-01), Hawley-Nelson et al.
patent: 5749847 (1998-05-01), Zewert et al.
patent: 5776746 (1998-07-01), Denney, Jr.
patent: 5830730 (1998-11-01), German et al.
patent: 5842477 (1998-12-01), Naughton et al.
patent: 6074667 (2000-06-01), Kinnunen et al.
patent: 6420176 (2002-07-01), Lisziewicz et al.
patent: 0574356 (1993-12-01), None
Verma et al (Nature 389: 239-242, 1997).
Anderson (Nature 392:25-30, 1998).
Romano et al (Stem Cells 18: 19-39, 2000).
Somia and Verma (Nature Reviews Genetics 1: 91-99, 2000).
Orkin and Motulsky (Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy, p. 1-38, Dec. 7, 1995).
Rosenfeld and Collins (Chest 109:241-252, 1996).
Boucher (TIG 12(3): 81-84, 1996).
Rosenecker (Eur. J. Med. 23(3): 149-156, Mar. 1998).
Boucher (J. Clin. Invest. 103(4): 441-445 Feb. 1999).
Feero (Gene Therapy, 4: 664-674, 1997).
Staedel et al (J. Invest. Dermatol. 102(5): 768-772, May 1994).
Machy et al (Proc. Nat. Acad. Sci. 85(21): 8027-8031, Nov. 1988).
Trubetskoy et al (Biochim. et Biophys. Acta. 1131(3): 311-313, 1992a).
Trubetskoy et al (Bioconjug. Chem. Jul. Aug. 3(4):323-7, 1992b).
Definition of “primary cell” retrieved from www.biochem.northwestern.edu/holmgren/ Glossary/Definitions/Def-P/primary—cell.html on Apr. 14, 2004.
Miller et al. (FASEB J. 9: 190-199, 1995).
Deonarain (Exp. Opin. Ther. Patents 8(1):53-69, 1998).
Crystal (Science 270: 404-410, 1995).
Feero et al. (1997) “Selection and use of ligands for receptor-mediated gene delivery to myogenic cells,” Gene Therapy 4:664-674.
Gao et al. (1996) “Potentiation of Cationic Liposome-Mediated Gene Delivery by Polycations,” Biochem. 35:1027-1036.
Trubetskoy et al. (1992) “Cationic liposomes enhance targeted delivery and expression of exogenous DNA mediated by N-terminal modified poly (L-lysine)-antibody conjugate in mouse lung endothelial cells,” Biochem. Biophys. Acta 1131:311-313.
Wagner et al. (1990) “Transferrin-polycation conjugates as carriers for DNA uptake into cells,” Proc. Natl. Acad. Sci. USA 87:3410-3414.
Alton et al. (1993) Nature Genet. 5:135-142.
Brant et al. (1997) Am. Fed. Med. Res. 45(1):159A.
Cheng (1996) Human Gene Ther. 7:275-282.
Chu et al. (1995) J. Biomed. Mat. Res. 29:1147-1154.
Chu et al. (1997) Clin. Orthop. Rel. Res. 340:220-229.
Ecker and Crooke (1995) BioTechnology 13:351-360.
Felgner et al. (1987) Proc. Natl. Acad. Sci. USA 84:7413-7417.
Gattei et al. (1997) Blood 89:2048-2059.
Jellinek et al. (1995) Biochem. 34:11363-11372.
Lasic (1992) Amer. Scientist 80:20-31.
Lee and Huang (1996) J. Biol. Chem. 271(14):8481-8487.
Li et al. (1993) Austr. New Zeal. J. Med. 23:205-212.
Lin et al. (1994) Nucl. Acids. Res. 22:5229-5234.
Pagratis et al. (1997) Nature Biotechnol. 15:68-73.
Stribling et al. (1992) Proc. Natl. Acad. Sci. USA 89:11277-11281.
Tam et al. (1994) Nucl. Acids. Res. 22:977-986.
Taxman et al. (1993) Anal. Biochem. 213:97-103.
Wagner et al. (1994) Adv. Drug Deliv. Rev. 14:113-135.
Wheeler et al. (1996) Proc. Natl. Acad. Sci. USA 93:11454-11459.
Raja-Walia et al. (1995) “Enhancement of liposome-mediated gene transfer into vascular tissue by replication deficient adenovirus,” Gene Therapy 2(8):521, Abstract only.
Kreuzer et al. (1996) “Adenovirus-assisted lipofection: efficient in vitro gene transfer of luciferase and cytosine deaminase to human smooth muscle cells,” Atherosclerosis 124:49-60.
Chemomordik et al. (1991) “Increased binding of liposomes to cells by electric treatment,” Biochim. Biophys. Acta 1070:193-197 and Abstract.
Jones et al. (1989) “Transient gene expression in electroporatedSolanumprotoplasts,” Plant Mol. Biol. 13:503-511.
Potter et al. (1984) “Enhancer-dependent expression of human κimmunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation,” Proc. Natl. Acad. Sci. USA 81:7161-7165.
Neumann et al. (1982) “Gene transfer into mouse lyoma cells by electroporation in high electric fields,” EMBO J. 7:841-845.
Mann et al. (1989) “Efficient Transfection of Insect Cells with Baculovirus DNA Using Electroporation,” J. Gen. Virol. 70:3501-3505; definition of “permeability,” Dictionary of Biochemistry and Molecular; Biology, Wiley & Sons, 2nd ed., 1989, p. 353.
Poste et al. (1976) “Lipid Vesicles as Carriers for Introducing Biologically Active Materials into Cells,” inMethods Cell Biol., Chapter 4 definition of “endocytosis,” Dictionary of Biochemistry and Molecular; Biology, Wiley & Sons, 2nd ed., 1989, p. 353.
“Membrane Fusion Involves Bilayer Adherence Followed by Bilayer Joining,” inMol. Biol. of the Cell, Garland Publishing, 1983, p. 305.
Margolis (1984) “Cell Interaction with Model Membranes,” Biochim. Biophys. Acta 779:161-189.
Schroeder et al. (1994) “Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior,” Proc. Natl. Acad. Sci. USA 91:12130-12134.
Weissmann et al. (1976) “Introduction of Missing Enzymes into the Cytoplasm of Cultured Mammalian Cells by Means of Fusion-Prone Liposomes,” Trans. Assoc. Am. Phys. 89:171-183.
Bolin et al. (1981) “Passage of Molecules through the Wall of the Gastrointestinal Tract,” J. Gastroent. 16(7):897-901.
Hapala (1997) “Breaking the Barrier: Methods for Reversible Permeabilization of Cellular Membranes,” Critical Reviews in Biotechnology 17(2):105-122.
“Liposomes in biological systems,” inLiposomes, A Practical Approach, Rickwood and Hames (eds.), IRL Press, NY, 1990, pp. 221-252.
Voet et al. (1995) Biochem., 2nd ed., Wiley and Sons, NY, p. 664.
Verma et al. (1997) “Gene therapy—promises, problems, and prospects,” Nature 389:239-242.
Anderson (1998) “Human gene therapy,” Nature 392:25-30.
Orkin (1995) Report and recommendations of the panel to assess the NIH investment in research on gene therapy, pp. 1-38.
You et al. (1997) “Surfactant-mediated gene transfer for animal cells,” Cytotechnology 25:45-52.
Staedel et al. (1994) “High-efficiency transfection of primary human keratinocytes with positively charged lipopolyamine: DNA complexes,” Soc. for Invest. Derma. 102(5):768-772.
Rosenberg (1975) “Penetration of phospholipases A2 and C into the squid (Loligo pealii) giant axon,” Experientia 31(12):1401-1403, Abstract only.
Allan et al. (1975) “Changes in lipid metabolism and cell morphology following attack by phospholipase C (Clostridium perfringens) on red cells or lymphocytes,” Biochim. Biophys. Acta 413(2):309-316.
Limbrick et al. (1975) “The perturbation of the human erythocyte membrane by phospholipase C,” J. Cell Sci. 19(2):341-355.
Thelestam et al. (1975) “Sensitive assay for detection of toxin-induced damage to the cytoplasmic membrane of human diploid fibroblasts,” Infect. Immun. 12(2):225-232.
Coleman et al. (1975) “Hydrolysis of erythrocyte membrane phospholipids by a preparation of phospholipase C from Clostridium Welchii. Deactivation of (CA-2+, Mg-2+)-ATPase and its reactivation by added lipids,” Biochim. Biophys. Acta 382(4):565-575.
Machy et al. (1998) “Gene transfer from targeted liposomes to specific lymphoid
Medlen & Carroll LLP
Regents of the Univeristy of California
Schnizer Richard
LandOfFree
Compositions for receptor/liposome mediated transfection and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions for receptor/liposome mediated transfection and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions for receptor/liposome mediated transfection and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3645455