Compositions for protein tyrosine phosphatases

Details Compositions for protein tyrosine phosphatases Compositions for protein tyrosine phosphatases

1995-03-30

1998-04-14

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530345, 514 15, A61K 3800, A61K 3802, C07K 500, C07K 700

Patent

active

057392781

ABSTRACT:
Methods and compositions useful for protein tyrosine phosphatases (PTPs) are disclosed. Peptides are provided which, in one aspect, are useful as substrates for the determination of PTP activity. In contrast to the current approaches, such peptides provide a general substrate for which variations in PTP enzymatic activity due to the assay are minimized. The present invention also discloses methods for determining the presence or amount of PTP. Because of the increased sensitivity of the methods, PTPs can be detected in situations where only limiting amounts of sample, e.g., tissue extracts or immunoprecipitates, are available.

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