Compositions for preventing and treating digestive organs...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Reexamination Certificate

active

07550437

ABSTRACT:
The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.

REFERENCES:
patent: 5541116 (1996-07-01), Bergmann
patent: 41 32 587 (1993-05-01), None
Vergnolle et al., Proc. Natl. Acad. Sci. USA, 1998, vol. 95, pp. 7766-7771.
Abstract for JP 11 171791, Kaneka Corp (Jun. 29, 1999), Database WPI, Section Ch, Week 199963, Derwent Publications Ltd., London, GB; AN 1999-424910, XP002230573.
Corvera et al., “Thrombin and Mast Cell Tryptase Regulate Guinea-Pig Myenteric Neurons Through Proteinase-Activated Receptors-1 and -2”,Journal of Physiology, vol. 517, No. 3, pp. 741-756 (Jun. 15, 1999).
Shirai, Takayuki. “I, Juunishichou Kaiyou,” Medicina (1994), vol. 31, No. 1, pp. 30-34.
McConalogue, K. et al. “Expression and Cellular Localization of Proteinase-Activated Receptor-2 (PAR-2) in the Gastrointestinal Tract,” Gastroenterology (1997) vol. 112, No. 4 suppl., p. A1171.
Vergnolle et al., “Proteinase-Activated Receptor 2 (PAR2)-activating Peptides: Identification of a Receptor Distinct from PAR2that Regulates Intestinal Transport”,Proc. Natl. Acad. Sci. USA, vol. 95, pp. 7766-7771 (Jun. 1998).
Kawabata, Atsushi et al. “Protease Juyoutai (PAR) no Seiriteki Yakuwari: tokuni Shoukaki kei Kinou e no Kanyo ni tsuite,” Nippon Yakurigaku Zasshi (1999), vol. 114, Suppl. 1, pp. 173-179.

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