Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds bacterium or component thereof or substance produced...
Patent
1997-10-14
1998-10-06
Loring, Susan A.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds bacterium or component thereof or substance produced...
424 43, 424 44, 4241501, 4241301, 5303871, A61K 3940, A01N 2502, A61L 904, C07K 1600
Patent
active
058173129
ABSTRACT:
The direct, concentrated local delivery of antibodies, and pooled human immunoglobulins in particular, to tissue surfaces (e.g., wounds, burns, etc.), and biomaterial implant surfaces significantly decreases the rate of infection at those sites and enhances healing. The immunoglobulins serve to opsonize circulating infectants for phagocytosis and killing, prior to microbial adhesion and biofilm formation, and neutralize bacterial toxins. The treatment methodology results in reduced inflammation, reduced complement and tissue damage, and reduced rejection of biomaterials and transplants.
REFERENCES:
patent: 5505945 (1996-04-01), Gristina et al.
Giridhar Girish
Gristina Anthony G.
Loring Susan A.
Medical Sciences Research Institute
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