Compositions for modifying nucleic acids

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S409000, C564S123000

Reexamination Certificate

active

07462451

ABSTRACT:
The present invention relates to compositions and methods for the preparation of modified nucleic acids. In particular, the present invention provides novel reagents and chemistries for the generation of linkers, modified phosphoramidites, and modified solid supports.

REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5011769 (1991-04-01), Duck et al.
patent: 5124246 (1992-06-01), Urdea et al.
patent: 5288609 (1994-02-01), Engelhardt et al.
patent: 5403711 (1995-04-01), Walder et al.
patent: 5409818 (1995-04-01), Davey et al.
patent: 5432272 (1995-07-01), Benner
patent: 5474796 (1995-12-01), Brennan
patent: 5538848 (1996-07-01), Livak et al.
patent: 5624802 (1997-04-01), Urdea et al.
patent: 5660988 (1997-08-01), Duck et al.
patent: 5710264 (1998-01-01), Urdea et al.
patent: 5792614 (1998-08-01), Western et al.
patent: 5846717 (1998-12-01), Brow et al.
patent: 5849481 (1998-12-01), Urdea et al.
patent: 5851770 (1998-12-01), Babon et al.
patent: 5858659 (1999-01-01), Sapolsky et al.
patent: 5882867 (1999-03-01), Ullman et al.
patent: 5912340 (1999-06-01), Kutyavin et al.
patent: 5914230 (1999-06-01), Liu et al.
patent: 5919626 (1999-07-01), Shi et al.
patent: 5925525 (1999-07-01), Fodor et al.
patent: 5952174 (1999-09-01), Nikiforov et al.
patent: 5958692 (1999-09-01), Cotton et al.
patent: 5985551 (1999-11-01), Brennan
patent: 5985557 (1999-11-01), Prudent et al.
patent: 5994069 (1999-11-01), Hall et al.
patent: 6001311 (1999-12-01), Brennan
patent: 6001567 (1999-12-01), Brow et al.
patent: 6001983 (1999-12-01), Benner
patent: 6013170 (2000-01-01), Meade
patent: 6017696 (2000-01-01), Heller
patent: 6037120 (2000-03-01), Benner
patent: 6045996 (2000-04-01), Cronin et al.
patent: 6051380 (2000-04-01), Sosnowski et al.
patent: 6063573 (2000-05-01), Kayyem
patent: 6068818 (2000-05-01), Ackley et al.
patent: 6090543 (2000-07-01), Prudent et al.
patent: 6110677 (2000-08-01), Western et al.
patent: 6110684 (2000-08-01), Kemper et al.
patent: 6121001 (2000-09-01), Western et al.
patent: 6127121 (2000-10-01), Meyer, Jr. et al.
patent: 6140496 (2000-10-01), Benner
patent: 6143877 (2000-11-01), Meyer et al.
patent: 6150097 (2000-11-01), Tyagi et al.
patent: 6183960 (2001-02-01), Lizardi
patent: 6210884 (2001-04-01), Lizardi et al.
patent: 6221583 (2001-04-01), Kayyem et al.
patent: 6248229 (2001-06-01), Meade
patent: 6348314 (2002-02-01), Prudent et al.
patent: 6458535 (2002-10-01), Hall et al.
patent: WO 97/27214 (1997-07-01), None
patent: WO 98/42873 (1998-10-01), None
patent: WO 99/67641 (1999-12-01), None
patent: WO 00/39587 (2000-07-01), None
Letsinger and Lunsdorf, “Synthesis of thymidine oligonucleotides by phosphite triester intermediates,” (1976) J. Am. Chem. Soc. 98:3655-3661.
Beaucage and Iyer, “Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach,” (1992) Tetrahedron, 48: 2223-2311.
Matray et al., “Synthesis of oligonucleotides containing 3′-alkylcarboxylic acids using a palladium labile oligonucleotide solid phase synthesis support,” (1997) Bioconjugate Chem 8:99-102.
Lyttle et al., “Versatile linker chemistry for synthesis of 3′-modified DNA,” (1997) Bioconjugate Chem. 8:193-198.
Agrawal and Iyer, Modified oligonucleotides as therapeutic and diagnostic agents, (1995) Curr. Opin. Biotechnol. 6:12-19.
Zhao et al., “Immobilization of oligodeoxyribonucleotides with multiple anchors to microchips,” (2001) Nucleic Acids Res. 29:955-959.
Barany, “Genetic Disease Detection and DNA Amplification Using Cloned Thermostable Ligase,” Proc. Natl. Acad. Sci USA 88, 189-93 (1991).
Habus et al., “A Mild and Efficient Solid-Support Synthesis of Novel Oligonucleotide Conjugates,” (1998) Bioconjugate Chem. 9: 283-291.
Stetsenko et al., “Genetic Disease Detection and DNA Amplification Using Cloned Thermostable Ligase ,” (2001) Bioconjugate Chem. 12:576-586.
Marshall, “Tumor suppressor genes,” Cell, 64: 313-326 (1991).
Hausch and Jäschke, “Multifuncational dinucleotide analogs for the generation of complex RNA conjugates,” (2001) Tetrahedron Lett. 57, 1261-1268.
Walton et al., “Evaluation of new linkers and synthetic methods for internal modified oligonucleotides,” (2002) Bioconjug Chem 13, 1155-1158.
Sojka et al., “A novel phosphoramidite method for automated synthesis of oligonucleotides on glass supports for biosensor development,” (2000) Appl Biochem Biotechnol 89, 85-103.
Vogel et al., “A substituted triaza crown ether as a binding site in DNA conjugates,” (2003) Chem Commun 21(8):1006-1007.
Wu, X., and Pitsch, S., “Synthesis and pairing properties of oligoribonucleotide analogues containing a metal-binding site attached to beta-D-allofuranosyl cytosine,” (1998) Nucleic Acids Res 26, 4315-4323.
Niemeyer, “The developments of semisynthetic DNA-protein conjugates,” 20:395-401(2002).
Guzaev et al., “A New Approach for Chemical Phosphorylation of Oligonucleotides at the 5′-Terminus,” Tetrahedron 51:9375-9384 (1995).
Caruthers et al., (1987) Methods Enzymol. 154:287-313.
Guzayev et al., (1995) Tetrahedron 51, 9375-9384.
Matysiak et al., (1997) Nucleosides & Nucleotides 16:855-861.
Nielsen, et al. Anticancer Drug Des. 8:53 63 [1993].
Trevisiol et al., (2000) Nucleosides, Nucleotides & Nucleic Acids 19:1427-1439.
Krotz et al., (2001) Bioorg. Med.Chem. Lett. 11:1863-1867.
Defrancq and Lhomme, (2001) Biorg. Med. Chem. Lett. 11:931-3.
Asseline and Thuong (1997) New J. Chem. 21: 5-17.
Zatsepin et al., (2002) Bioconjugate Chem. 13(4):822-830.
Forget et al., (2001) Tetrahedron Lett. 42, 7829-7832.
Podyminogin et al., (2001) Nucleic Acids Res. 29:5090-5098.
Lindroos et al., (2001) Nucleic Acids Res. 29:e69.
Dombi et al., (2002) Synthesis 6: 816-824.
Tilquin et al., (2001) Bioconjugate Chem. 12:451-457.
Karino et al., (2001) Nucleic Acids Res. 29: 2456-2463.
Ruth, (1994) Methods in Molecular Biology 26, 167-185.
Salo et al., (1999) Bioconjugate Chem. 10:815-823.
Forget et al., (2001) Chem. Eur. J. 7: 3976-3984.
Weinberg, Science, 254: 1138-1146 (1991).
Lyamichev et al., Nat. Biotech., 17:292 (1999).
Hall et al., PNAS, USA, 97:8272 (2000).
Hovinen et al., (1993) Tetrahedron Lett. 34:5163-5166.
Montserat et al., (1993) Nucleotides, Nucleosides 12:967-971.
Allawi, H.T. & SantaLucia, J., Jr. Thermodynamics and NMR of internal G. T mismatches in DNA. Biochemistry 36, 10581-94 (1997).
Pon and Yu (1997) Nucleic Acids Res. 25: 3629-363.
Greenberg and Kahl (2001) J.Org.Chem. 66:7151-7154.
Czaplinski and Sheppard, (2001) J. Am. Chem. Soc. 123:8618-8619.
Watterson et al., (2000) Langmuir 16, 4984-4992.
Steel et al., (2000) Biophys. J. 79, 975-81.
Shchepinov et al., (1997) Nucleic Acids Res. 25, 1155-1161.
Jäschke et al., (1993) Tetrahedron Lett. 34, 301-304.
Greenwald et al., (2000) Crit. Rev. Ther. Drug Carrier Syst. 17, 101-61.
Bonora et al., (1997) Bioconjugate Chem. 8, 793-797.
Jäschke et al., (1994) Nucleic Acids Res. 22, 4810-4817.
Jäschke et al., (1996) Nucleosides, Nucleotides 15, 1519-1529.
Afanassiev et al., (2000) Nucleic Acid Res. 28, E66-e66.
Hermanson, G.T. (1996) Bioconjugate techniques. Academic Press, pp. 185-186.
Urata et al., (1993) Tetrahedron Lett. 34,4015-4018.
Horn et al., (1997) Nucleic Acids Res. 25, 4842-4849.
McBride et al., (1988) Biotechniques 6, 362-7.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compositions for modifying nucleic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions for modifying nucleic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions for modifying nucleic acids will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4023089

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.