Compositions for manipulating the lifespan and stress...

Details Compositions for manipulating the lifespan and stress... Compositions for manipulating the lifespan and stress...

2004-07-01

2009-06-09

Davis, Ruth A (Department: 1651)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

C435S366000

Reexamination Certificate

active

07544497

ABSTRACT:
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.

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