Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1994-04-26
1995-10-17
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
436173, 546 2, 556 49, 514492, 514836, 424 9323, A61B 5055
Patent
active
054588707
ABSTRACT:
Methods and diagnostic compositions are disclosed for enhancing magnetic resonance imaging which utilize a paramagnetic metal cluster. Magnetic resonance contrast media containing Z.sup.+ [Mn.sub.12 X.sub.12 (OYR).sub.16l (L).sub.4 ].sup.-, where OYR is an oxyacid such as benzoic acid, acetic acid, methyl sulphonic acid, methyl phosphonic acid; L is a neutral donor such as water, alcohol, pyridine, or other amines; X is a chalcogen, such as O or S; and Z is a pharmaceutically acceptable counterion are disclosed. Z may also be a paramagnetic counter ion, such as a high spin metal cluster. The paramagnetic cluster may optionally be complexed or conjugated to a carrier compound capable of altering the paramagnetic metal cluster's biodistribution, increasing its selectivity of tumor localization, and amplifying its proton relaxivity.
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Perlepes et al., Inorganic Chemistry 30:1665-1668 (1991).
Boyd et al., J. American Chemical Society 110:8537-8539 (1988).
Caneschi, A. et al., J. American Chemical Society 113:5873-5874 (1991).
de Vries, N. et al., American Chemical Society Meetings Abstract #795 (1992).
Deutsch Edward A.
Moore Dennis A.
Hollinden Gary E.
Mallinckrodt Medical Inc.
Stierwalt Brian K.
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