Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1992-09-10
1996-05-07
Jones, W. Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 6, C07H 2100, C12Q 168, A61K 4800
Patent
active
055147860
ABSTRACT:
Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
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Bruice Thomas
Cook Phillip D.
Guinosso Charles J.
Kawasaki Andrew M.
ISIS Pharmaceuticals Inc.
Jones W. Gary
Schreiber David
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