Compositions for inhibiting restenosis

Details Compositions for inhibiting restenosis Compositions for inhibiting restenosis

1994-11-23

1997-08-19

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 21, 514 23, 514 54, 514 60, 536103, 530810, 530812, 530813, A61K 31735, C08B 3716

Patent

active

056588941

ABSTRACT:
Polyionic derivatives of cyclodextrins and methods for preparing these derivatives are provided in which a polyionic derivative of cyclodextrin is combined with a growth factor, preferably a heparin binding growth factor. These compositions are of low solubility and are applied directly to the location of a wound. By virtue of the low solubility, the compositions remain in place at the site of application and slowly release growth factor. In an alternative embodiment, the cyclodextrin derivatives are administered in the absence of growth factor and are used to absorb growth factor present in the body at the location of the wound in order to prevent overstimulation of the wound response.

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