Compositions for improving circulatory performance

Details Compositions for improving circulatory performance Compositions for improving circulatory performance

1988-06-06

1990-12-25

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514280, 514284, A61K 31675, A61K 3144

Patent

active

049803441

ABSTRACT:
Compositions having a compound from the family of protoberberines, especially coreximine, are used in conjunction with a cardiac glycoside. The composition and therapeutic method of administering the composition, orally and otherwise, increases the contractility of the heart as shown by a positive inotropic effect. The positive inotropic effect is observed over a wide therapeutic index.

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patent: 3910938 (1975-10-01), Ikekawa et al.
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Kulkarni et al.--Japan J. Pharmacol. 22, 11-16 (1972).
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Comptes Rendus Societe de Biologie, 127; 1938, pp. 1022-1024 (Mercier).
Soto et al.--Rev. Assoc. Med. Argent, 41:3062-3068 (1933).
Soto et al.--Rev. Assoc. Med Argent, 47, 2498-2501 (1933).
Chopra et al.--Ind. Jour. Med. Res., XIX 4, Apr. 1932.

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