Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Reexamination Certificate
2002-10-16
2004-05-25
Dodson, Shelley A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
C424S060000, C424S400000, C424S401000
Reexamination Certificate
active
06740313
ABSTRACT:
The present invention relates to a cosmetic and/or dermatological composition that can produce on skin a long-lasting and non-covering coloration similar to that of a natural tan, comprising, in a cosmetically acceptable medium, at least one pigment, which may be obtained by extraction with a solvent chosen from organic and aqueous-organic solvents of a culture medium of micromycetes of the Monascus type.
The invention also relates to the use of the composition for giving the skin a coloration similar to that of naturally tanned skin.
Nowadays, it is important to look healthy, and tanned skin is always a sign of good health. However, a natural tan is not always desirable because it requires long exposure to UV radiation, for example, UV-A radiation, which causes the tanning of the skin but may induce an adverse change therein, such as in sensitive skin or skin that is continually exposed to solar radiation. It is therefore desirable to find an alternative to a natural tan that is compatible with the requirements of such skin types.
Most of the cosmetic products intended for artificially tanning the skin are based on carbonyl derivatives which, by interacting with the amino acids in the skin, allow the formation of coloured products.
It is known that dihydroxyacetone (DHA) is an advantageous product which is commonly used in cosmetics as an agent for artificially tanning the skin; when applied to the skin, such as to the face, it can give a tanning or bronzing effect which is similar in appearance to that which may result from prolonged exposure to sunlight (a natural tan) or light from a UV lamp.
One drawback of DHA is the length of time the coloration takes to develop: for example, several hours (3 to 5 hours in general) can be required for the coloration to be revealed. There is thus an increasing demand for self-tanning products that can act quickly and can give a coloration that is closer to that of a natural tan.
Therefore, efforts are still underway to find novel compounds and novel compositions which can give the skin an artificial coloration close to that of a natural tan in a simple, effective, fast, and risk-free manner.
The pigments derived from filamentous fungi of the Monascus type have long been known as colouring agents for food products, pharmaceutical products, and cosmetics. Filamentous fungi of the Monascus type are obtained by fermentation. The strains usually used are the strains of the genus
Monascus anka, Monascus purpurea, Monascus ruber
and
Monascus pilosus,
all of which are readily available. These pigment-forming micromycetes produce six types of pigments which differ in their degree of unsaturation, their auxochromic functions, and the size of their aliphatic chain. These pigments may be intracellular or extracellular and can have different shades depending on their chemical structure. Distinguished pigments include, for example, yellow pigments of the ankaflavin type and of the monascin type; orange pigments of the monoascorubrin and rubropunctatin types; and red pigments of the monoascorubramine and rubropunctamine types. The orange pigments can be derived directly from the secondary metabolism of the fungus, whereas the yellow pigments and red pigments are metabolites derived from a reduction reaction of the orange pigments to obtain the yellow pigments, and an amination reaction of the orange pigments to obtain the red pigments.
Patent document JP 04-023880 discloses cosmetic compositions containing an extract derived from the mutant strain R300-30 from
Monascus anka
(FERM No. 11135) and optionally other standard UV screening agents; the extract is used for its UVA- and UVB-absorbing properties. This document does not mention the use of these compositions for artificially colouring the skin.
Patent document JP 64-90109 discloses cosmetic compositions containing a liquid extract of a culture of a mould of the genus Monascus. This liquid extract contains proteolytic enzymes, vitamins, peptides and various amino acids. These compositions are used for their moisturizing and detergent properties on the skin.
Patent documents JP 60-149 512 and JP 10-194928 disclose makeup compositions containing Monascus pigments linked to a regenerated silk fibroin powder. These documents do not mention the use of these compositions for artificially colouring the skin.
Patent document JP 57-145 159 discloses cosmetic facial care compositions based on natural pigments (for example Monascus) associated with a porous magnesium and/or calcium aluminate silicate powder. This document does not mention the use of these compositions for artificially colouring the skin.
Patent document WO 01/43711 discloses skincare compositions containing a combination of an extract of Monascus and an ascorbic acid derivative (palmitate ascorbyl, sodium ascorbyl or phosphate ascorbyl) or a retinol derivative (retinal or an ester thereof). These compositions are used for their regulatory activity on skin sebum, their stimulatory activity on collagen synthesis by the skin fibroblasts, and their phytooestrogenic properties. This document does not mention the use of these compositions for artificially colouring the skin.
After considerable research conducted in the field of artificial colouring of the skin, the inventors have now discovered that the inclusion, as a skin-colouring agent, of at least one pigment that may be obtained by extraction with a solvent chosen from organic and aqueous-organic solvents of a culture medium of micromycetes of the Monascus type in, or for the manufacture of, a cosmetic and/or dermatological composition makes it possible to give the skin, very soon after the composition has been applied thereto, a long-lasting and non-covering coloration close to that of a natural tan.
One aspect of the present invention is thus a cosmetic and/or dermatological composition that can produce on the skin a long-lasting and non-covering coloration similar to that of a natural tan, comprising, in a cosmetically acceptable medium, at least one pigment which may be obtained by extraction with a solvent chosen from organic and aqueous-organic solvents of a culture medium of micromycetes of the Monascus type.
Another aspect of the invention is the inclusion of at least one pigment that may be obtained by extraction with a solvent chosen from organic and aqueous-organic solvents of a culture medium of micromycetes of the Monascus type, in, or for the manufacture of, a cosmetic composition, with the purpose of giving the skin a long-lasting and non-covering coloration close to that of a natural tan.
Another aspect of the present invention is a process for giving the skin a long-lasting and non-covering coloration similar to that of a natural tan, comprising applying to the skin an effective amount of at least one pigment which may be obtained by extraction with a solvent chosen from organic and aqueous-organic solvents of a culture medium of micromycetes of the Monascus type in a cosmetic composition containing it.
The composition and the process in accordance with the invention make it possible to obtain an artificial coloration close to that of a natural tan in a short amount of time. Thus, an immediate coloration can be obtained, which can allow visualization of the application and consequently visualization of better homogeneity in the spreading of the composition on the skin and thus visualization of the resulting coloration. Furthermore, the artificial coloration obtained on the skin according to the invention can be extremely close to that of a natural tan.
In accordance with the present invention, the expression “composition that produces on the skin a long-lasting and non-covering coloration similar to that of a natural tan” means a formulation with an affinity for the skin which allows it to give the skin
a coloration, which is not removed either with water or with a solvent, and which withstands both rubbing and washing with a solution containing surfactants; and
a coloration, which does not have a tendency to opacify the skin.
Such a long-lasting and non-covering colora
Candau Didier
Elguidj Irène
Forestier Serge
Seyler Nathalie
Dodson Shelley A.
L'Oreal (S.A.)
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