Compositions for generating T cell immunity against carbohydrate

Details Compositions for generating T cell immunity against carbohydrate Compositions for generating T cell immunity against carbohydrate

1993-04-27

1998-09-15

Minnifield, Nita

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

4242771, 4241741, 4241841, 530403, 530300, 530402, 435 691, 514 8, A61K 3900, A61K 3170, A61K 4505, A61K 4700

Patent

active

058075593

ABSTRACT:
The present invention relates to a novel class of immunologically active compounds, to processes for their production and to their use in therapy. In particular, the invention provides immunogenic peptide-carbohydrate conjugates useful for generating T cell immunity against tumor-associated carbohydrate structures, or against carbohydrate structures expressed on infectious agents and/or infected host cells. The immunogenic conjugate comprises a peptide component capable of binding a MHC class I molecule and a carbohydrate component having the same immunogenic characteristics of the carbohydrate structure on the tumor cell, infectious agent or the infected cells.

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