Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-06
1998-01-27
Degen, Nancy
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352542, 4352557, 4353201, 435325, 536 231, 536 241, C12P 2102, C07H 2104, C12N 1581, C12N 1585
Patent
active
057121141
ABSTRACT:
Hybrid genes comprising a nucleotide sequence encoding a preprocollagen signal sequence operatively linked to a nucleotide sequence encoding a heterologous protein are disclosed. The hybrid genes are useful for secretion of heterologous proteins from host cells. In a preferred embodiment, the signal sequence of the human preprocollagen .alpha.1(I) protein is linked to a heterologous protein of interest to allow for secretion of the protein from Hansenula polymorpha cells.
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Ferenz Catherine R.
Hammill Linda
Mankovich John A.
BASF - Aktiengesellschaft
DeConti, Jr. Giulio A.
Degen Nancy
Kara, Phd. Catherine J.
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