Compositions for enhancing transport of molecules into cells

Details Compositions for enhancing transport of molecules into cells Compositions for enhancing transport of molecules into cells

2004-04-29

2008-12-23

Schnizer, Richard (Department: 1635)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C536S024500, C536S031000

Reexamination Certificate

active

07468418

ABSTRACT:
Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.

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