Compositions for enhancing magnetic resonance imaging

Details Compositions for enhancing magnetic resonance imaging Compositions for enhancing magnetic resonance imaging

1992-07-10

1993-09-21

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

534 16, 436173, 1286534, 514492, 514836, 556 50, G01N 2408, A61K 3128, C07F 1300

Patent

active

052466965

ABSTRACT:
Substantially nontoxic manganese or gadolinium complexes of compounds of the formula: ##STR1## wherein n and m=1, 2, 3 or 4, y=1, 2 or 3, and x is selected from the group consisting of S, CHOH and CHSH, are useful for enhancing magnetic resonance images of body organs and tissues. Illustrative manganese and gadolinium complexes of such compounds include disodium [[(2-hydroxytrimethylene)dinitrilo]tetraaceto]manganese(II) and sodium [[(2-hydroxytrimethylene)dinitrilo]tetraaceto)gadolinium(III).

REFERENCES:
Novomesky, P. et al. Proc. Conf. Coord. Chem. 8th pp. 305-308 (1980).
Klyachina, K. N. et al. Chem. Abs. 70:86064d (1969). Ogawa, E. et al. Japan J. Pharmacol. 20:275-81 (1972).
Morishita, M. et al. Chem. Abs. 97:188296f (1982).
Kuhn, A. Chem. Abs. 71:573e (1969).
Brucher, E. et al. Inorg. Nocl. Chem. Letters 12:161-171 (1976).
Dwek, R. A. et al. Eur. J. Biochem. 21:204-209 (1971).

Affiliated with

Also associated with

Rating

Compositions for enhancing magnetic resonance imaging does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions for enhancing magnetic resonance imaging, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions for enhancing magnetic resonance imaging will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1048110