Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing
Reexamination Certificate
2005-02-22
2010-02-23
Arnold, Ernst V (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C424S401000, C424S647000
Reexamination Certificate
active
07666829
ABSTRACT:
The present invention describes therapeutic compositions comprising one or more minerals, including trivalent iron, divalent manganese and salts thereof, suitable in facilitating synthesis and deposition of connective tissue matrix, particularly rich of elastin and collagen, and mitogenic potential in human dermal fibroblasts. It also describes the phenomenon in which stimulation of elastogenesis by arterial SMC associates with a net decrease in proliferation of these cell types. The present invention also describes methods of treatment of human skin fibroblasts and arterial smooth muscle cells. The therapeutic compositions of the present invention comprise one or more of trivalent iron or divalent manganese or salts thereof and may be combined with an elastic tissue digest.
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Bunda Severa
Hinek Aleksander
Jimenez Felipe
Mitts Thomas
Arnold Ernst V
Human Matrix Sciences, LLC
Pepper Hamilton LLP
The Hospital For Sick Children
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