Compositions for diabetes treatment and prophylaxis

Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...

Reexamination Certificate

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C424S400000, C424S489000, C424S499000, C424S774000

Reexamination Certificate

active

06949261

ABSTRACT:
An isolate from the leaves ofGymnema sylvestre, having a specified molecular weight, is useful for the treatment of diabetes. The isolate has a molecular weight at least about 3000 Daltons as determined by molecular weight cut-off filtration. Glucose metabolism in a human patient is regulated by dosage forms that contain the aforesaid isolate from the leaves ofGymnema sylvestre, optionally in combination with a non-metabolizable polysaccharide such as the exudate ofSterculia urens.

REFERENCES:
patent: 4761286 (1988-08-01), Hiji
patent: 4824672 (1989-04-01), Day et al.
patent: 4883788 (1989-11-01), Day et al.
patent: 4988682 (1991-01-01), Kozikowski
patent: 5063210 (1991-11-01), Lange, III et al.
patent: 5137921 (1992-08-01), Kensho et al.
patent: 5176937 (1993-01-01), Kurihara et al.
patent: 5178899 (1993-01-01), Kurihara et al.
patent: 5242693 (1993-09-01), Kurihara et al.
patent: 5244887 (1993-09-01), Straub
patent: 5484777 (1996-01-01), Lange, III et al.
patent: 5641511 (1997-06-01), Kuhrts
patent: 5730988 (1998-03-01), Womack
patent: 5773427 (1998-06-01), Day
patent: 5843909 (1998-12-01), Atsuchi et al.
patent: 5900240 (1999-05-01), Tomer et al.
patent: 6133237 (2000-10-01), Noll et al.
patent: 6187753 (2001-02-01), Noll et al.
patent: 6376481 (2002-04-01), Bruce et al.
patent: 6455068 (2002-09-01), Licari
patent: WO 95/10292 (1995-04-01), None
Fletcher, J.I. et al. “High-resolution solution structure of gurmarin, a sweet-taste-suppressing plant polypeptide”. Eur. J. Biochem. 264 (1999): 525-533.
Kazumasa Shimizu, et al. “Suppression of Glucose Absorption by Some Fractions Extracted fromGymnema sylvestreLeaves,” J. Vet. Med. Sci., vol. 59 (4); pp. 245-251 (1997).
Harry G. Preuss, M.D., et al., “Comparative Effects of Chromium, Vanadium and Gymnema Sylvestre on Sugar-Induced Blood Pressure Elevations in SHR,” Journal of American College of Nutrition, vol. 17(2); pp. 116-123 (1998).
Yumiko Nakamura, et al., “Fecal Steroid Excretion is Increased in Rats by Oral Administration of Gymnemic Acids Contained inGymnema sylvestreLeaves,” J. Nutr., vol. 129, pp. 1214-1222 (1999).
K. Baskaran, et al. “Antidiabetic Effect of a Leaf Extract FromGymnema sylvestrein Non-Insulin-Dependent Diabetes Mellitus Patients,” Journal of Ethnopharmacology, vol. 30, pp. 295-305 (pp. 1990).
E.R.B. Shanmugasundaram, et al., “Use ofGymnema sylvestreLeaf Extract in the Control of Blood Glucose in Insulin-Dependent Diabetes Mellitus,” Journal of Ethnopharmacology, vol. 30, pp. 281-294 (1990).
E.R.B. Shanmugasundaram, et al., “Possible Regeneration of the Islets of Langerhans in Streptozotocin-Diabetic Rats GivenGymnema sylvesreLeaf Extracts,” Journal of Ethnopharmacology, vol. 30, pp. 265-279 (1990).
Y. Okabayashi, et al., “Effect ofGymnema sylvestre, R.Br. on Glucose Homeostatis in Rats,” Diabetes Research and Clinical Practice, vol. 9 (2), pp. 143-148 (1990).
D.J. Joffe, “Effect of Extended ReleaseGymnema SylvestreLeaf Extract . . . ,” Diabetes in Control Newsletter, Issue 76(1): pp. 1-4 (Oct. 30, 2001).
K.R. Shanmugasundaram, et al., Enzyme Changes and Glucose Utilization in Diabetic Rabbits: The Effect ofGymnema sylvestre, R.Br., Journal of Ethnopharmacology, vol. 7, pp. 205-234 (1983).
S.K. Baveja, et al., “Examination of Natural Gums and Mucilages as Sustaining Materials in Tablet Dosage Forms—Part II, ” Indian Journal of Pharmaceutical Sciences, vol. 51 (4), pp. 115-118 (Mar., 1988).
Toshiaki Imoto et al., “A Novel Peptide Isolated From the Leaves ofGymnema sylvestre. . . ”, Comp. Biochem. Physiol. 100A(2): 309-314 (1991).

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