Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1988-07-08
1992-04-14
Nucker, Christine
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530395, 530413, 530416, 530828, C07K 322, C07K 1500, C07K 1506
Patent
active
051049759
ABSTRACT:
Compositions useful for detecting ras gene proteins are described consisting of GTP and a protein having an apparent reduced molecular weight of about 115,000-120,000 daltons, or fragments derived therefrom, that stimulate ras protein guanosine triphosphatase activity. Also described are methods whereby the compositions are used to identify cancer therapeutics.
REFERENCES:
patent: 4404188 (1983-09-01), Donahoe et al.
Cales et al, Nature (England), 332(6164) pp. 548-551, Apr. 7, 1988, "The Cytoplasmic Protein Gap is Implicated as the Target for Regulation by the Ras Gene Product".
Jackson B. Gibbs, et al., 1988, PNAS (U.S.A.), 85:5026-5030.
McCormick, et al., 1988, Cold Spring Harbor Symposia on Quantitative Biology, LIII:849-854, Cold Spring Harbor Laboratory.
Adari, H., et al., 1988, Science, 240: 518-521.
Sigal, Irving S., 1988, Nature, 332:485-486.
McCormick, F., et al., 1988 CSH, (Abstract Only).
Trahey, M., et al., (Abstract Only).
Halenbeck Robert F.
Koths Kirston E.
McCormick Francis P.
Trahey Mary M.
Cetus Corporation
Giotta Gregory J.
Halluin Albert P.
Nucker Christine
Scheiner Laurie A.
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