Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Patent
1991-03-20
1993-08-10
Hill, Jr., Robert J.
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
436813, 530350, 530395, 530416, 530828, 935 11, 935 13, 935111, 435 71, G01N 33566, A61K 3702
Patent
active
052348393
ABSTRACT:
Compositions useful for detecting ras gene proteins are described consisting of GTP and a protein having an apparent reduced molecular weight of about 115,000-120,000 daltons, or fragments derived therefrom, that stimulate ras protein guanosine triphosphatase activity. Also described are methods whereby the compositions are used to identify cancer therapeutics.
REFERENCES:
patent: 4762706 (1988-08-01), McCormick et al.
McCormick et al., (1988) Coldspring Harbor Symposia on Quant. Biology, vol. LIII, pp. 849-854.
Trahey et al. Molecular and Cellular Biology, vol. 7, No. 1, Jan. 1987, pp. 541-544.
Trahey et al. Science, vol. 238, 8 Apr. 1987, pp. 542-545.
Adari et al., Science, vol. 240, 22 Apr. 1988, pp. 518-521.
Halenbeck Robert F.
Koths Kirston E.
McCormick Frank P.
Trahey Mary M.
Cetus Oncology Corporation
Giotta Gregory J.
Gruber Lewis S.
Hill Jr. Robert J.
Scheiner Laurie
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