Compositions for dental anesthesia

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai

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514729, 514309, 514330, 514331, 514447, 514537, 514620, 514626, 514818, A61K 31045

Patent

active

060750596

ABSTRACT:
Anesthetic compositions that achieve enhanced anesthesia of the peripheral nerves located in the mouth region of a subject or patient are provided. Such anesthetic compositions comprise water, a local anesthetic agent, and a sugar alcohol at a concentration of at least 0.1 moles/L i.e., at least 0.1 M. A method of anesthetizing a peripheral nerve of the mouth region is also provided. The method comprises: providing an anesthetic composition comprising water, a local anesthetic agent, and a sugar or, preferably, a sugar alcohol at a concentration of at least 0.1 M; and administering said anesthetic composition to a site proximate to said peripheral nerve.

REFERENCES:
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"Comparison of Neural Blockade and Pharmacokinetics after Busarachnoid Lidocaine in the Rhesus Monkey. II: Effects of Volume, Osmolality, and Baricity" by Denson, et al., Anesth Anlg, 1983;62: 995-1001.
"Osmotic Opening of Perineurial Diffusion Barrier in Peripheral Nerve" by Kristensson, et al., Neuropathology and Applied Neurobiology, 1976, 2, 479-488.
Chapter 11 "Neuroanatomical correlates" Local Anesthetics by Rudolph H. de Jong, Mosby, St. Louis, Baltimore, Boston, Chicago, London, Madrid, Philadelphia, Sydney, Toronto., 1994.
"Anesthetic efficacy and heart rate effects of the supplemental intraosseous injection of 2% mepivacaine with 1:20,000 levonordefrin" by Guglielmo, et al., Oral Surgery, Oral Medicine, Oral Pathology, vol. 87, No. 3, Mar. 1999, pp. 841-293.
"Anesthetic efficacy of the intraosseous injection of 0.9 mL of 2% lidocaine (1:100,000 epinephrine) to augment an inferior alveolar nerve block" by Reitz, et al., Oral Surgery, Oral Medicine, Oral Pathology, 1998; 86:516-523.
"Anesthetic efficacy of the supplemental intraosseous injection of 3% mepivacaine in irreversible pulpitis" by Reisman, et al., Oral Surgery, Oral Medicine, Oral Pathology, vol. 84, No. 6, Dec. 1997, pp. 676-682.
"Anesthetic Efficacy of the Supplemental Intraosseous Injection of 2% Lidocaine with 1:100,000 Epinephrine in Irreversible Pulpitis" by Nusstein, et al., Journal of Endodontics, vol. 24, No. 7, Jul. 1998, pp. 487-491.
"Anestetic Efficacy of the Intraosseous Injection after an Inferior Alveolar Nerve Block" by Dunbar, et al., Journal of Endodontics, vol. 22, No. 9, Sep. 1996, pp. 481-486.
Thesis: "The Anesthetic Efficacy of a Combination of 2% Lidocaine with Epinephrine and Mannitol in Human Inferior Alveolar Nerve Block" by Mark Stephen Palo, B.A., D.D.S., Thesis, The Ohio State University, Cataloged on Feb. 25, 1998.
Thesis: "The Anesthetic Efficacy of a Combination of 2% Lidocaine with 1:100,000 Epinephrine and 0.5 Molar Mannitol in Human Inferoir Alveolar Nerve Block" by Ronald Michael Wolf, D.D.S., M.S., The Ohio State University, Cataloged on Oct. 15, 1998.

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