Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Reexamination Certificate
2007-05-22
2007-05-22
Jones, Dameron L. (Department: 1618)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
C424S001110, C424S001650, C536S022100
Reexamination Certificate
active
10445696
ABSTRACT:
Cyclic amidinium containing compounds and their methods of preparation are described. Compositions containing these compounds facilitate delivery of biologically active polymers to cells in vitro and in vivo.
REFERENCES:
patent: 6013240 (2000-01-01), Behr et al.
patent: 6126964 (2000-10-01), Wolff et al.
patent: 6339067 (2002-01-01), Wolff et al.
Adami RC et al. “Metabolic Stability of Glutaraldehyde Cross-Linked Peptide DNA Condensates.” J Pharm Sci. 1999 vol. 88 No. 8 pp. 739-746.
Anderson MW et al. “Dihydroimidazoles in Synthesis: C-Alkylation of 1-Benzyl-2-(α-lithioalkyl)-4,5-dihydroimidazoles and a Synthesis of Alkanoic Acids.” J Chem Soc Perkin Trans. I 1986 pp. 205-209.
Askitoglu E et al. “Transition Reactions.” Helv Chim Acta 1985 vol. 68 pp. 750-759.
Barnett C et al. “Diazepines. Part IV. Dihydrodiazepiniu, Salts from the Condensation Reaction between NN'-Disubstituted Ethylenediamines and β-Dicarbonyl Compounds.” J Chem Soc C 1966 pp. 93-95.
Blessing T et al. “Template Oligomerization of DNA-Bound Cations Produces Calibrated Nonametric Particles.” J Am Chem Soc 1998 vol. 120 pp. 8519-8520.
Boussif O et al. “A Versatile Vector for Gene and Oligonucleotide Transfer into Cells in Culture and in vivo: Polyethylenimine.” Proc Natl Acad Sci USA. 1995 vol. 92 pp. 7297-7301.
Chimishkyan AL et al. “Relationships in the Transmission of Substituted Ureas.” J Org Chem USSR 1985 vol. 21 pp. 1955-1961.
Coll JL et al. “In vivo delivery to tumors of DNA complexed with linear polyethylenimine.” Hum Gene Ther. 1999 vol. 10 No. 10 pp. 1659-1666.
Fernandez BM et al. “Synthesis and Hydrolysis of Substituted Salts. Behavior of the Degradation Products on Varying pH.” J Heterocyclic Chem 1987 vol. 24 pp. 1717-1724.
Ferrari S et al. “Polyethylenimine shows properties of interest for cystic fibrosis gene therapy.” Biochim Biophys Acta. 1999 vol. 1447 No. 2-3 pp. 219-225.
Garcia J et al. “New synthetic “tricks” using old reagents. A mild method for the conversion of RCONHR' to RCONHR″.” Tett Lett 1982 vol. 23 No. 10 pp. 1127-1128.
Goula D et al. “Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system.” Gene Ther 1998 vol. 5 No. 5 pp. 712-717.
Gruseck U et al. “2-Alkylidenimidazolidine—Synthese, Basizitat,1H und13C-NMR-Spektren.” Chem Ber. 1987 vol. 120 pp. 2053-2064.
Hafferl W et al. “Activated Hydrogens in Compounds Related to Thiamine.” Biochemistry 1963 vol. 2 pp. 1298-1305.
Jaenicke L et al. “N,N'-Diaryl-Äthylendiamine als Modelle der Tetrahydrofolsäure in Nicht-Enzymatischen Reaktionen.” Ann Chem 1959 vol. 624 pp. 120-137.
Jeong JH et al. “DNA transfection using linear poly(ethylenimine) prepared by controlled acid hydrolysis of poly(2-ethyl-2-oxazoline).” J Controlled Release 2001 vol. 73 No. 2-3 pp. 391-399.
Krammer U et al. “The “Zip” Reaction: A New Method for Ring Expansion; Synthesis of 17- and 21-Membered Polyaminolactams.” ACIEE 1977 vol. 16 pp. 861-862.
Krammer U et al. “Die “Zip”-Reaktion: Eine neue Ringerweiterungsreaktion. Synthese von 17-, 21- und 25-gliedrigen Polyaminolactamen.” Helv Chim Acta 1978 vol. 61 pp. 1342-1352.
Lasic DD et al. “The Structure of DNA-Liposome Complexes.” J Am Chem Soc 1997 vol. 119 pp. 832-833.
Leonard NJ et al. “Small Charged Rings. IV. Expansion of the Aziridinium Ring by Reaction with Nitriles. A New Type of Benzylating Agent.” J Org Chem 1965 vol. 30 pp. 817-821.
Leonard NJ et al. “Small Charged Rings. IX. Expansion of the Azirine Ring.” J Am Chem Soc 1967 vol. 89 pp. 4456-4465.
Lloyd D et al. “Diazepines. Part 23. The Formation of Structure of 1,5-Diaza- and 5-Aza-1-oxa-pentadienium Salts and the Use in the Preparation of 2,3-Dihydro-1,4-Diazepinium Salts.” J Chem Soc Perkin Trans I 1978 pp. 1453-1460.
May M et al. “Synthetic and Degradative Investigations of the Structure of Folinic Acid-SF.” J Am Chem Soc 1951 vol. 73 pp. 3067-3075.
New RRC “Liposomes: A Practical Approach” Chapter 1, introduction. ed. R.C. New IRL Press at Oxford University Press, Oxford, 1990 pp. 1-32.
Niven R et al. “Biodistribution of Radiolabeled Pipid-DNA Complexes and DNA in Mice.” J Pharm Sci 1998 vol. 87 pp. 1292-1299.
Perillo I et al. “Reaction of an Asymmetric Imidazolinium Compound with Nucleophiles.” J Chem Soc Perkin Trans I 1975 pp. 894-896.
Pfeil E et al. “Synthesis of Imidazolines and Imidazolidines by the Reaction of Aziridinium Tetrafluoroborate with Nitriles and Benzylideneaniline.” Angew Chime Int Ed Engl 1965 vol. 44 pp. 518-519.
Salerno A et al. “Reduction of Substituted 1H-4,5-Dihydroimidazolium Salts.” J Heterocyclic Chem 1992 vol. 29 pp. 1725-1733.
Stach H et al. “Synthesis of Macrocyclic Compounds by Ring Enlargement.” Tettrahedron 1988 vol. 44 pp. 1573-1590.
Seymour RB et al. “Polymer Chemistry: An Introduction” New York Oxford University Press 1990 pp. 193-209, 250-263, 281-295.
Strzelecka TE et al. “A 23Na-NMR study of sodium-DNA interactions in concentrated DNA solutions at low-supporting electrolyte concentration.” Biopolymers 1990 vol. 30, No. 7-8 pp. 803-814.
Strzelecka TE et al. “Phase transitions of concentrated DNA solutions in low concentrations of 1:1 supporting electrolyte.” Biopolymers 1990 vol. 30 No. 1-2 pp. 57-71.
Trubetskoy VS et al. “Layer-bylayer deposition of oppositely charged polyelectrolytes on the surface of condensed DNA particles.” Nucleic Acids Res 1999 vol. 27 pp. 3090-3095.
Trubetskoy VS et al. “Caged DNA Does Not Aggregate in High Ionic Strength Solutions.” Bioconjugate Chem 1999 vol. 10 pp. 624-628.
Trubetskoy VS et al. “Quantitative Assessment of DNA Condensation.” Anal Biochem 1999 vol. 267 pp. 309-313.
Trubetskoy VS et al. “Self-Assembly of DNA-Polymer Complexes Using Template Polymerization.” Nucleic Acids Res 1998 vol. 26 pp. 4178-4185.
von Harpe A et al. “Characterization of commercially available and synthesized polyethylenimines for gene delivery.” J Controlled Release 2000 vol. 69 No. 2 pp. 309-322.
Wilson RW et al. “Counterion-induced condesation of deoxyribonucleic acid. a light-scattering study.” Biochemistry 1979 vol. 18 No. 11 pp. 2192-2196.
Wolff JA et al. “Direct gene transfer into mouse muscle in vivo.” Science 1990 vol. 247 pp. 1465-1468.
Monahan Sean D.
Trubetskoy Vladimir
Ekena Kirk
Johnson Mark K.
Jones Dameron L.
Mirus Bio Corporation
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