Compositions for controlled release of a biologically active...

Details Compositions for controlled release of a biologically active... Compositions for controlled release of a biologically active...

2006-09-26

2006-09-26

Sheikh, Humera N. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

C424S488000

Reexamination Certificate

active

07112339

ABSTRACT:
A composition for controlled release of a biologically active agent from a carrier. The biologically active agent is heparin or a related biologically active acidic polysaccharide and the carrier is a sol-gel derived silica xerogel. The xerogel is derived from a tetraalkoxysilane such as tetrethoxysilane (TEOS) and part of the tetraalkoxysilane is replaced by an organomodified alkoxysilane, preferably an akylsubsitituted alkoxysilane. The invention also includes a method for the preparation of this composition.

REFERENCES:
patent: 5804318 (1998-09-01), Pinchuk et al.
patent: 5858280 (1999-01-01), Zhang et al.
patent: WO 97/45367 (1997-12-01), None
patent: WO 00/50349 (2000-08-01), None
Kuncova, G., Guglielmi, M., Dubina, P and Safar B. Lipase immobilized by sol-gel technique in layers. 1995. Collect. Czech. Chem. Commun. vol. 60, pp. 1573-1577.
Chen, Hongmei et al.: “Preparation and Blood Compatibility of New Silica-chitosan Hybrid Biomaterials”,Art. Cells, Blood Subs. and Immob. Biotech., 26(4), 431-6 (1998).
Kim et al., “Heparin Immobilization onto Sol-gel Derived Organic-inorganic Hybrid Network”, 127Chemical Abstracts14053 (1997).
Negent, et al., “Local Drug Delivery and Tissue Engineering Regulate Vascular Injury”; 128Chemical Abstracts145217 (1998).

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