Compositions for controlled delivery of pharmaceutical compounds

Details Compositions for controlled delivery of pharmaceutical compounds Compositions for controlled delivery of pharmaceutical compounds

1992-03-13

1994-03-22

Webman, Edward

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424423, 424425, 424427, 424430, 424433, 424434, 424435, 424436, 424486, 424487, 424488, 424499, 514944, 514951, 514781, 5147726, A61K 910, A61K 4736, A61K 4734

Patent

active

052962288

ABSTRACT:
Sustained release pharmaceutical compound delivery compositions and methods for their production are disclosed wherein ion exchange resin particles are loaded with releasably bound pharmaceutical compounds and incorporated in an aqueous reversibly gelling polymeric solution. The pores of the ion exchange resin are sufficiently small to lock in the pharmaceutical compound without exposure to the large polymer molecules. The pharmaceutical compound remains bound within the pores of the ion exchange resin particles until after administration to a target tissue site where small ions migrate into the pores and initiate an exchange reaction.

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patent: 4795644 (1989-01-01), Zentner
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patent: 4983392 (1991-01-01), Robinson
patent: 4996047 (1991-02-01), Kelleher et al.
patent: 5071646 (1991-12-01), Malkowska et al.

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