Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1995-08-04
1998-09-15
Adams, Donald E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241841, 4241861, 530324, 530333, 530826, 514 2, 514 12, 514934, 535 5, 535974, A61K 3921
Patent
active
058075526
ABSTRACT:
A multimer of monomers non-covalently held together by interactive peptide linkers is provided for the enhancement of the immunogenicity of a substance. These multimers are useful for stimulating or suppressing the immune system, detecting the presence of antibodies, bypassing MHC restriction in an animal, the effective presentation of antigen, suppressing autoimmune disease, inducing cytokine production, adsorption, treating a defective immune system and for use as an adjuvant.
REFERENCES:
patent: 3791932 (1974-02-01), Schuurs et al.
patent: 3949064 (1976-04-01), Bornstein et al.
patent: 4174384 (1979-11-01), Ullman et al.
patent: 4578770 (1986-03-01), Mitani
patent: 4596792 (1986-06-01), Vyas
patent: 4599230 (1986-07-01), Milich et al.
patent: 4599231 (1986-07-01), Milich et al.
patent: 4601903 (1986-07-01), Frasch
patent: 4608251 (1986-08-01), Mia
patent: 5077195 (1991-12-01), Blalock et al.
patent: 5229490 (1993-07-01), Tam
International Search Report dated Oct. 29, 1996 (UTFG:162P).
Blalock and Smith, "Hydropathic Anti-Complementarity of Amino Acids Based on the Genetic Code," Biochemical and Biophysical Research Communications, 121(1):203-207, May 1984.
Bost et al., "Similarity Between the Corticotropin (ACTH) Receptor and a Peptide encoded by an RNA That is Complementary to ACTH mRNA," Proc Natl Acad Sci, USA, 82:1372-1375, March 1985.
Chang and Meienhofer, "Solid-Phase Peptide Synthesis Using Mild Base Cleavage of N.sup..alpha. -Fluorenylmethyloxycarbonylamino Acids, Exemplified by a Synthesis of Dihydrosomatostatin," Int J Peptide Protein Res, 11:246-249, 1978.
Goodman, "Immunogenicity & Antigenic Specificity," In:Basic Human Immunology, Stites, M.D. and Terr, M.D. (eds), Chapter 8, pp. 101-108, Appleton & Lange, Norwalk, Connecticut/San Mateo, CA., 1991.
Guillet et al., "Immunological Self, Nonself Discrimination," Science, 235:865-870, Feb. 1987.
Hale et al., "T Cell Multideterminant Regions in the Human Immunodeficiency Virus Envelope: Toward Overcoming the Problem of Major Histocompatibility Complex Restriction," International Immunology, 1(4):409-415, 1989.
Kyte and Doolittle, "A Simple Method for Displaying the Hydropathic Character of a Protein," Journal of Molecular Biology, 157:105-132, 1982.
R. B. Merrifield, "Solid Phase Peptide Synthesis: The Synthesis of a Tetrapeptide," Journal of the American Chemical Society, 85(14):2149-2154, July 1963.
Sette et al., "Structural Analysis of Peptides Capable of Binding to More Than One Ia Antigen," Journal of Immunology, 142(1):35-40, Jan. 1989.
James P. Tam, "Synthetic Peptide Vaccine Design: Synthesis and Properties of a High-Density Multiple Antigenic Peptide System," Proc Nat Acad Sci, USA, 85:5409-5413, Aug. 1988.
Hughes, Jr. Thomas K.
Smith Eric M.
Stanton G. John
Adams Donald E.
Board of Regents , The University of Texas System
Stucker Jeffrey
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