Compositions for co-administration of interleukin-3 mutants and

Details Compositions for co-administration of interleukin-3 mutants and Compositions for co-administration of interleukin-3 mutants and

1994-02-04

1998-06-30

Fitzgerald, David L.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 851, 435 6952, A61K 3820, A61K 3819

Patent

active

057729921

ABSTRACT:
The invention provides compositions comprising a human interleukin-3 (hIL-3) variant or mutant protein (mutein) and another colony stimulating factor, cytokine, lymphokine, interleukin, or hematopoietic growth factor. The compositions are useful for the therapeutic co-administration of the proteins, as for example in hematopoietic reconstitution. factors or IL-3 variants.

REFERENCES:
patent: 4438032 (1984-03-01), Golde et al.
patent: 4810643 (1989-03-01), Souza
patent: 4877729 (1989-10-01), Clark et al.
patent: 4959455 (1990-09-01), Clark et al.
patent: 4999291 (1991-03-01), Souza
patent: 5114711 (1992-05-01), Bell et al.
patent: 5218092 (1993-06-01), Sasaki et al.
Lokker, N.A.,et al. (1991) EMBO J. 8: 2125-31.
Lokker, N.A., et al. (1991) J. Biol. Chem. 266: 10624-31.
Olins, P.O. et al. (1995) J. Biol. Chem. 270: 23754-60.
Aglietta, M., et al., Stem Cells Dayt 2(83):83-7 (1993).
Appelbaum, F.R. Cancer 72(11 Suppl):3387-92 (1993).
Bodine, D.M.et al., Blood 78(4):914-20 (1991)
Brandt, J., et al. Blood 79(3):634-641 (1992).
Brandt, J.E., et al., Blood 83(6):1507-1514 (1994).
Briddell, R.A. et al., Blood 76(3):516-522 (1990).
Broxmeyer, H.E., et al. J. Immun 141:3852-3862 (1988).
Broxmeyer, H.E., et al. Blood 77(10):2142-2149 (1991).
Brugger, W., et al., Blood 81(10):2679-2584 (1993).
Bruno, E., et al., Blood 73 (3):671-677 (1989).
Bruno, E., et al., Blood 77(11):2339-2346 (1991).
Donahue, R.E., et al., Science 241:1820-1823 (1988).
Donahue, R.E., et al., Annals N. Y. Acad. of Sci 511:10-16 (1987).
Emerson, S.G., et al., J. Clin. Invest. 82:1282-1287 (1988).
Farese, A.M., et al., Blood 82(10):3012-3018 (1993).
Ganser, A.,et al., Blood 79(10):2583-2591 (1992).
Gordon, M.S. et al., Blood 80(2):302-307 (1992).
Grosh, W.W. et al., Clin Immunol Immunopathol 62(1 Pt 2):s25-38 (1992).
Heyworth, C.M., et al., Growth Factors 2(2-3): 197-211 (1990).
Iscova, N.N., et al., J. Immun 142:2332-2337 (1989).
Ikebuchi, K., et al., Proc. Natl. Acad. Sci. USA 84:9035-9039 (1987).
Jacobsen, S.E.W.et al., Blood 80(3):678-687 (1992).
Jacobsen, F.W., et al., Blood 84(3):775-779 (1994).
Jacobsen, S.E.W., et al., J. Exp. Med. 181:1357-1363 (1995).
Kaushansky, K., et al., Proc. Natl. Acad. Sci. USA 92:3234-3238 (1995).
Kawano, Y., et al., Blood 77(10):2118-2121 (1991).
Kawano, Y., et al., Stem Cells 12:514-520 (1994).
Krumwieh, D., et al., Int J Cell Cloning 1(229):229-47 (1990).
Lopez, A.F., et al., Proc. Natl. Acad. Sci. USA 89:11842-11846 (1992).
Mayani, H., et al., Blood 81(12):3252-3258 (1993).
MacVittie, T.J., et al., Blood 84(8):2515-2522 (1994).
Metcalf, D. et al., Blood 79(11):2861-2866 (1992).
Metcalf, D. Stem Cells Dayt 2(1):1-11 (1993).
Metcalf, D. Blood 82(12):3515-3523 (1993).
Moore, M.A. Cancer 65(3 Suppl):836-44 (1990).
Moore, M.A. Blood 78(1):1-19 (1991).
Nand, S., et al., Blood 83(2):357-360 (1994).
Neidhart, J.A. Cancer Supplement 72(11):3381-3386 (1993).
Ogawa, M. Blood 81(11):2844-53 (1993).
Pietsch, T.,et al., Blood 80(5):1199-206 (1992).
Ploemacher, R.E., et al., Leukemia 7(9):1381-1388 (1993).
Rennick, D., et al., Experimental Hematology 22:136-141): (1994).
Robinson, B.E., et al., J. Clin. Invest. 79:1648-1652 (1987).
Sekhsaria, S. et al., Blood 81(8):2152-2130 (1993).
Seiff, C.A.,et al., Blood 73(3):688-693 (1989).
Smith, S.L., et al., Exp. Hem. 21(7):870-77 (1993).
Sonoda, Y., et al., Proc. Natl. Acd. Sci. USA 85:4360-4364 (1988).
Stahl, C.P., et al., Blood 80(10):1479-2485 (1992).
Sutherland, H.J., et al., Blood 81(6):1465-1470 (1993).
Takaue, Y., et al., Blood 76(2):330-5 (1990).
Tsuji, K., et al., Blood 79(11):2855-60 (1992).
Warren, D.J. et al., J. of Immunology 140:94-99 (1988).
S.S. Fojo et al, Biochem., vol. 17, No. 15, 3109-3115.

Affiliated with

Also associated with

Rating

Compositions for co-administration of interleukin-3 mutants and does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions for co-administration of interleukin-3 mutants and , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions for co-administration of interleukin-3 mutants and will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1856170