Compositions for clones containing DNA sequences associated with

Details Compositions for clones containing DNA sequences associated with Compositions for clones containing DNA sequences associated with

1990-09-24

1993-04-27

Moskowitz, Margaret

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 691, 435 91, 4351723, 935 9, 935 17, 935 78, C07H 2100, C12Q 168

Patent

active

052063526

ABSTRACT:
Genomic and cDNA clones of human genes which are selectively amplified or overexpressed in multidrug-resistant human tumor cells were isolated. Such clones may be used as probes in diagnostic tests to detect chemotherapy-resistant tumor cells and to predict tumor response to chemotherapy. The complete nucleotide sequence of the coding region of the human mdr1 gene and the complete corresponding amino acid sequence are disclosed.

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