Compositions for boron neutron capture therapy and methods there

Details Compositions for boron neutron capture therapy and methods there Compositions for boron neutron capture therapy and methods there

1993-06-03

1997-07-15

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

568 4, 568 5, C04F 502

Patent

active

056485328

ABSTRACT:
Boron neutron capture therapy can utilize X.sub.y B.sub.20 H.sub.17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH.sub.3, and Na.sub.2 B.sub.10 H.sub.9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may have embedded within their bilayers carboranes to increase the amount of delivered .sup.10 B and/or to increase the tumor specificity of the liposome.

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