Compositions for applying active substances to or through the sk

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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424401, 424 63, A61K 9127

Patent

active

055409342

ABSTRACT:
A cosmetic or medical composition for topical application to the skin. It results in the transdermal passage of an active ingredient, or in the introduction of such agent into the skin. The essential components of such compositions are a phospholipid, a lower aliphatic alcohol of two to four carbon atoms, optionally with propylene glycol, water and a compatible active ingredient. The alcohol content is generally from 20 to 50%, and when propylene glycol is present, the combined percentage of alcohol and glycol being up to about 70%. The composition are suitable for the topical application of a wide variety of cosmetic and pharmaceutical compounds.

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patent: 5004611 (1991-04-01), Leigh
patent: 5077057 (1991-12-01), Szoka
patent: 5154930 (1992-10-01), Popesur
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Riaz et al. In Pharmaceutical Dosage Forms. Disperse Systems, vol. 2; Lieberman, H. A., Rieger, M. M., Banker, G. S., Eds, Marcel Dekker, Inc. New York and Basel, 1988 pp. 567-602.
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Touitou et al. Enhanced Permeation Of Theophylline Through The Skin And Its Effect On Fibroblast Proliferation. Int. J. Pharm. 70 (1991) 159-166.

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