Compositions for, and methods of, treating atherosclerosis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S399000

Reexamination Certificate

active

06900241

ABSTRACT:
Disclosed and claimed are cocoa extracts, compounds, combinations thereof and compositions containing the same, such as polyphenols or procyanidins, methods for preparing such extracts, compounds and compositions, as well as uses for them, especially a polymeric compound of the formula An, wherein A is a monomer of the formula:wherein n is an integer from 2 to 18, such that there is at least one terminal monomeric unit A, and one or a plurality of additional monomeric units; R, X, Y and Z are as defined in the specification.

REFERENCES:
patent: 4698360 (1987-10-01), Masquelier
patent: 4797421 (1989-01-01), Ariga et al.
patent: 4840966 (1989-06-01), Hara et al.
patent: 5527552 (1996-06-01), Todd, Jr.
patent: 5554645 (1996-09-01), Romanczyk
patent: 5720956 (1998-02-01), Rohdewald
patent: 5292885 (1993-11-01), None
Waterhouse, A.L., et al.,Antioxidants in Chocolate, The Lancet, (Sep. 21, 1996).
Khushbaktova et al.,Study of Hypolipidemic Properties of Polymeric Proanthocyanidins from Plants Used in Folk Medicine, Khimiko-Farmatsevticheskii Zhurnal, v. 23, n. 9, 1111-1115 (1989), Russian original w/ /Translation.
Dietary Flavonoids in Atherosclerosis Prevention, The Annals of Pharmacotherapy, 29:627-628 (Jun. 1995).
Negre-Salvayre,Anne, et al.,Ultraviolet-Treated Lipoproteins as a Model System for the Study of the Biological Effects of Lipid Peroxides on Cultured Cells. III. The Protective Effect of Antioxidants(Probucol, Catechin, Vitamin E)Against the Cytotoxicity of Oxidized LDL Occurs in Two Different Ways, Biochimica et Biophysica Acta, 1096:291-300 (1991).
Guo, Qiong, et al.,Studies on Protective Mechanisms of Four Components of Green Tea Polyphenols Against Lipid Peroxidation in Synaptosomes, Biochimica et Biophysica Acta, 1304:210-222 (1996).
Viana, Marta, In VitroEffects of a Flavonoid-rich Extract on LDL Oxidation, Atherosclerosis, 123:83-91 (1996).
Meunier, Marie-Therese,Inhibition of Angiotensin I Converting Enzyme by Flavanolic Compounds: In Vitro and In Vivo Studies, Planta Medica, 53:12-15 (1987).
Laughton, et al.,Inhibition of Mammalian 5-Lipoxygenase and Cyclo-Oxygenase By Flavonoids and Phenolic Dietary Additives, Biochem. Pharmacol, 42:1673-1681 (1991).
Kondo, K.,Anti-Arteriosclerosis Functions of Polyphenol Contained in Cacao Beans, Second International Nutrition Symposium on Chocolates and Cocoa(Sep. 20, 1996).
Kondo, K.,Inhibition of LDL Oxidation by Cocoa, Lancet, vol. 348, p. 1514 (1996).
Zieglader, G., et al.,Antioxidative Effects of Cocoa, CCB:Review for Chocolate, Confectionery and Baker(Dec. 1983).
Osawa,Antioxidant Activity of Cocoa Extracts, Chocolate and Cocoa Association of Japan, Symposium(Sep. 27, 1995)(Translated Abstract of Presentation).
Sakane, T.,Immunoactivity of Cocoa Extracts, Chocolate and Cocoa Association of Japan, Symposium(Sep. 27, 1995) (Translated Abstract of Presentation).
Verhagen, J.V., et al.,Nitric Oxide Radical Scavenging by Wines, J. Agric. Food Chem. 44:373-3734 (1996).
Uchida, Shinji, et al.,Inhibitory Effects of Condensed Tannins on Angiotensin Converting Enzyme, Japan. J. Pharmacol. 43:242-246 (1987).
Ho, Chi-Tang, et al.,Antioxidative Effect of Polyphenol Extract Prepared from Various Chinese Teas, Preventive Medicine, vol. 21. pp. 520-525 (1992).
Sanz, M.J., et al.,Isolation and Hypotensive Activity of a Polymeric Procyanidin Fraction from Pistacia Lentiscus L., Pharmazie, vol. 47, pp. 466-467 (1992).
Cheng, Juei-Tang, et al.,Antihypertensive Principles from the Leaves of Melastoma Candidum, Planta Medica Journal of Medicinal Plant Research59:405-407 (1993).
Xie, B., et al.,Antioxidant Properties of Fractions and Polyphenol Constituents from Green, Oolong and Black Teas, Proc. Natl. Sci. Conc. Rebub. China B., vol. 17, No. 2, pp. 77-84 (1993).
Tebib, Katia et al.,Dietary Grape Seed Tannins Affect Lipoproteins, Lipoprotein Lipases and Tissue Lipids in Rats Fed Hypercholesterolemic Diets, J. Nutr., vol. 124, pp. 2451-2457 (1994).
Ariga, Toshiaki and Yusa, Katsumi,Antioxidative Properties of Oligomeric Proanthocyanidins and Their Applications, Fragrance Journal Special Edition/Functions and Applications in Recent Food Materials(1994), Original w/ translation.
Salah, Nida et al.,Polyphenolic Flavanols as Scavengers of Aqueous Phase Radicals and as Chain-Breaking Antioxidants, Archives of Biochemistry, vol. 322, No. 2, pp. 339-346 (1995).
Polette, A., et al.,N-3 Fatty Acid-induced Lipid Peroxidation in Human Platelets is Prevented by Catechins, Thromb. Haemost., vol. 75, No. 6, pp. 945-949 (1996).
Kelly, Collete, et al.,Modulation of Human Platelet Function by Food Flavonoids, Biochemical Society Transactions24:197S (1996).
Mueller, W.S.,Antioxidative Properties of Cacao and Their Effect on Butterroil, Journal of Dairy Science, 37:754-760 (1954).
Andriambeloson, Emile,Nitric Oxide Production and Endothelium-dependent Vasorelaxation Induced by Wine Polyphenols in Rat Aorta, British Journal of Pharmacology, vol. 120, pp. 1053-1058 (1997).
Chang, Wen-Chang,Inhibition of Platelet Aggregation and Arachidonate Metabolism in Platelet by Procyanidins, Leukotriences and Essential Fatty Acids, 38:181-188 (1989).
Chang, Wen-Chang,Inhibition of Platelet Activation and Endothelial Cell Injury by Flavan-3-ol and Saikosaponin Compounds, Prostaglandins, Leukotrienes and Essential Fatty Acids, 44:51-56 (1991).

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