Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-02-01
2005-02-01
Brumback, Brenda (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002600
Reexamination Certificate
active
06849602
ABSTRACT:
The invention provides a method of alleviating neuropathic pain in a subject by administering a neuropathic pain alleviating amount of prosaposin receptor agonist to the subject. The invention also provides a method of inhibiting the onset of neuropathic pain in a subject by administering neuropathic pain alleviating amount of prosaposin receptor agonist to the subject. The present invention also provides prosaposin receptor agonists and the use of these agonists for stimulating neurite outgrowth, inhibiting neural cell death, promoting myelination and inhibiting neural demyelination. In addition, there is provided a method of inhibiting sensory or motor neuropathy by contacting neuronal cells with a composition comprising an effective inhibiting amount of prosaposin receptor agonist.
REFERENCES:
patent: 5470582 (1995-11-01), Supersaxo et al.
patent: 5571787 (1996-11-01), O'Brien et al.
patent: 5696080 (1997-12-01), O'Brien et al.
patent: 6268347 (2001-07-01), O'Brien
patent: 6559124 (2003-05-01), O'Brien et al.
patent: 6590074 (2003-07-01), O'Brien et al.
patent: 0246753 (1987-11-01), None
patent: 0288243 (1988-10-01), None
patent: 0405467 (1991-01-01), None
Hong et al.,Intracellular Adhesion Molecule-1 Expression Induced by Interleukin(IL)-1B or IB Fragment is blocked by an IL-1 Receptor Antagonist and a Soluble IL-1 Receptor. Journal of Neuroimmunology 44(2):163-170 (Jun. 1993).
Kotani et al.,Prosaposin Facilities Sciatic Nerve Regeneration In Vivo, Journal of Neurochemistry 66(5):2019-2025 (May 1996).
Albright, “Intrathecal Baclofen in Cerebral Palsy Movement Disorders,”Journal of Child Neuropathy II(Suppl. I) S29-S35 (1996).
Banks et al., “Permeability of the Blood-Brain Barrier to Peptides: An Approach to the Development of Therapeutically Useful Analogs,”Peptides 13: 1289-1294 (1992).
Bennett et al., “A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man,”Pain 33: 87-107 (1988).
Bennett, “An Animal Model of Neuropathic Pain: A Review,”Muscle&Nerve 16: 1040-1048 (1993).
Calcutt et al., “Tactile allodynia and formalin hyperalgesia in streptozoticin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine”Pain68:293-299 (1996).
Campana et al., “Prosaptide, a Peptide derived from Prosaposin, Includes Motor Endplate Sprouting and Prevents Taxol Neuropathy,”Society for Neurosciences, 21:554(1995).
Hefti et al., “Chronic Administration Of Nerve Growth Factor and Other Neurotrophic Factors in the Brain,”Neurobiology of Aging 9: 689-690 (1988).
Jackowski, “Neural Injury Repair: Hope for the Future as Barriers to Effective CNS Regeneration Become Clearer,”British Journal of Neurosurgery 9: 303-317 (1995).
Kim et al., “An Experimental Model for Peripheral Neuropathy Produced by Segmental Spinal Nerve Ligation in the Rat,”Pain, 50:355-363 (1992).
Kotani et al., “A Hydrophilic Peptide Comprising 18 Amino Acid Residues of the Prosaposin Sequence Has Neurotrophic Activity In Vitro and In Vivo,”J. Neurochem 66: 2197-2220 (1996).
Lekan et al., “Behavioral reponses following an experimental neuropathy in primates,”Soc. Neurosci. Abst. 18:287 (1992).
McMahon et al., “Peripheral neuropathies and neurotrophic factors: animal models and clinical perspectives,”Curr. Opinion in Neurobiology 5: 616-624 (1995).
Merck Manual, Sixteenth Edition (1992) Berkow, ed., Merck Research Laboratories, Rathway, NJ, pp. 1416-1419.
Myers, “The Pathogenesis of Neuropathic Pain,”Regional Anesthesia 20(3): 173-184 (1995).
O'Brien et al., “Identification of the Neurotrophic Factor Sequence of Prosaposin,”FASEB J. 9: 681-685 (1995).
Onoprienko et al., “Synthesis and Immunogenic properties of Peptides Corresponding to 59-72 and 25-36 sequences of Human IL-2,”Bioorg. Khim. 15(7): 908-921 (1989) (English language abstract).
Pachner et al., “An Immunodominant Site of Acetylcholine Receptor,”Immunology Letters 20: 199-204 (1989).
Palacek et al., “Responses of spinothalmic tract neurons to mechanical and thermal stimuli are increased in an experimental model of peripheral neuropathy in primates,”Soc. Neurosci. Abst. 18:287 (1992).
Rudinger et al., “Characteristics of the Amino Acids as Components of a Peptide Hormone Sequence” inPeptide Hormones, University Park Press, (1976) pages 1-7.
Sano et al., “Protection by Prosaposin Against Ischemia-Induced Learning Disability and Neuronal Loss,”Biochem. Biophys. Res. Commun. 204(2): 994-1000 (1994).
Schubert et al., “Multiple Influences of a Heparin-Binding Growth Factor on Neuronal Development”The Journal of Cell Biology 104: 635-643 (1987).
Seltzer et al. “A Novel Behavioral Model of Neuropathic Pain Disorders Produced in Rats by Partial Sciatic Nerve Injury,”Pain 43(2): 205-218 (1990).
Sprang et al., “Cytokine Structural Taxonomy and Mechanisms of Receptor Engagement,”Curr. Opinion, Struct. Biol. 3: 816 (1993).
Triguero et al., “Capillary Depletion Method for Quantitation of Blood Brain Barrier Transport of Circulating Peptides and Plasma Proteins,”J. Neurochem. 54: 1882-188 (1990).
Tsarbopoulos et al., “Peptide and Protein Mapping by252Cf-Plasma Desorption Mass Spectrometry”Anal. Biochem., V. 171 pages 113-123 (1988).
Wall et al., “Autonomy Following Peripheral Nerve Lesions: Experimental Anaethesia Dolorosa”Pain 7: 103-113 (1979).
Weiler et al., “Synthesis and Charachterization of a Bioactive 82-Residue Sphingolipid Activator Protein, Saposin C,”Journal of Molecular Neuroscience, 4(3): 161-172 (1993).
Brumback Brenda
Fish & Richardson P.C.
Hayes Robert C.
The Regents of the University of California
LandOfFree
Compositions for alleviating neuropathic pain with... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions for alleviating neuropathic pain with..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions for alleviating neuropathic pain with... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3450888