Compositions for alleviating inflammation and oxidative...

Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from camellia

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S756000, C424S725000

Reexamination Certificate

active

11088323

ABSTRACT:
An antioxidant-promoting composition that increases antioxidant defense potential in a subject is disclosed comprisingBacopa monnieraextract; milk thistle extract, ashwagandha powder, green tea extract,Gotu kolapowder,Ginko bilobaleaf extract;Aloe verapowder; turmeric extract; and N-acetyl cysteine. The antioxidant-promoting composition of the invention safely induces cellular antioxidant potential to achieve an overall net decrease in oxidative stress without the undesirable side-effects associated with the individual components of the antioxidant-promoting composition. Also disclosed is a method for reducing the undesirable side-effects of free radicals in a subject by administering to a subject in need of such antioxidants an effective amount of antioxidant-promoting composition of the invention.

REFERENCES:
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 5854287 (1998-12-01), Weglicki
patent: 5939395 (1999-08-01), Yu et al.
patent: 6093404 (2000-07-01), Kattan
patent: 6372265 (2002-04-01), Saito
patent: 6495170 (2002-12-01), Smit et al.
patent: 6646013 (2003-11-01), Barker et al.
patent: 2002/0086067 (2002-07-01), Choi et al.
patent: 2003/0072823 (2003-04-01), Fleischner
Albert, “The Role of C-Reactive Protein in Cardiovascular Disease Risk,”Curr. Cardio. Rep., 2000; vol. 2: pp. 274-279.
Alexandrakis, et al., “The Relation Between Bone Marrow Angiogenesis and the Proliferation Index Ki-67 in Multiple Myeloma,”J. Clin. Pathol., 2004; vol. 57: pp. 856-860.
Baeuerle, et al., “IκB: A Specific Inhibitor of the NF-κB Transcription Factor,”Science, 1988; vol. 242: pp. 540-546.
Al-Shaer, “C-Reactive Protein and Risk of Colon Cancer,”JAMA, 2004; vol. 291, No. 23: pp. 2818-2819.
Anderson, et al., “Differential Response of Human Ovarian Cancer Cells to Induction of Apoptosis by Vitamin E Succinate and Vitamin E Analogue, α-TEA,”Cancer Res., 2004; vol. 64: pp. 4263-4269.
Baker, et al., “Reduced RBC Versus Plasma Microvascular Flow Due to Endotoxin,”Circul. Shock, 1986; vol. 20: pp. 127-139.
Barbosa, et al., “Decreased Oxidative Stress in Patients with Ulcerative Colitis Supplemented with Fish Oil ω-3 Fatty Acids,”Nutrition, 2003; vol. 19: pp. 837-842.
Bhattacharya, et al., “Antioxidant Activity of Glycowithanolides fromWithania sominfera,” Ind. J. Exper. Biol., 1997; vol. 35: pp. 236-239.
Bhattacharya, et al., “Antixidant Activity ofBacopa monnierain Rat Frontal Cortex, Striatum and Hippocampus,”Phytother. Res., 2000; vol. 14: pp. 174-179.
Bogarty, et al., “Biological Profiles in Subjects with Recurrent Acute Coronary Events Compared with Subjects with Long-standing Stable Angina,”Circulation, 2001; vol. 103: pp. 3062-3068.
Bolibar, et al., “Short-term Prognostic Value of Lipid Measurements in Patients with Angina Pectoris,”Thromb. Haemost., 2000; vol. 84: pp. 955-960.
Bose, et al., “Membrane Lipid Peroxidation by UV-A: Mechanism and Implications,”Biotech. App. Biochem., 1990; vol. 12: pp. 557-561.
Boyd-Kimball, et al., “Rodent Aβ(1-42) Exhibits Oxidative Stress Properties Similar to Those of Human Aβ(1-42): Implications for Proposed Mechanisms of Toxicity,”J. Alzh. Dis., 2004; pp. 515-525.
Bridi, et al., “The Antioxidant Activity of Standardized Extract ofGinkgo biloba(EGb 761) in Rats,”Phytother. Res., 2001; vol. 15: pp. 449-451.
Chaudhri, et al., “Reactive Oxygen Species Facilitate the In Vitro an In Vivo Lipopolysaccharide-induced Release of Tumor Necrosis Factor,”J. Immun., 1989; vol., 142, No. 4; pp. 1290-1294.
Cole, et al., “Metal-catalyzed Oxidation of Alpha Synuclein: Helping to Define the Relationship Between Oligomers, Protofibrils and Filaments,”JBC Papers in Press, Dec. 21, 2004; Man. M409946200.
Dawes, et al., “Rheumatoid Arthritis: Treatment which Controls the C-Reactive Protein and Erythrocyte Sedimentation Rate Reduces Radiological Progression,”Brit. J. Rheum., 1986; vol. 25: pp. 44-49.
Demopoulos, “The Basis of Free Radical Pathology,”Fed. Proc., 1973; vol. 32, No. 8: pp. 1859-1861.
Dessein, et al., “Cardiovascular Risk in Rheumatoid Arthritis Versus Osteoarthritis” Acute Phase Response Related Decreased Insulin Sensitivity and High-density Lipoprotein Cholesterol as well as Clustering of Metabolic Syndrome Features in Rheumatoid Arthritis,Arthr. Res., 2002; vol. 4, No. R5: pp. 1-6.
Drash, et al., “Effect of Probucol on Development of Diabetes Mellitus in BB Rats,”Amer. J. Card.,1988; vol. 62: pp. 27B-30B.
D'Souza, et al., “Brine Shrimp Lethality Assay ofBacopa monnieri,” Phytother. Res., 2002; vol. 16: pp. 197-198.
Duh, et al., “Tumor Necrosis Factor α Activates Human Immunodeficiency Virus Type 1 Through Induction of Nuclear Factor Binding to the NF-κB Sites in the Long Terminal Repeat,”Proc. Natl. Acad. Sci. USA, 1989; vol. 86: pp. 5974-5978.
Eck, et al., “Low Concentrations of Acid-Soluble Thiol (Cysteine) in the Blood Plasma of HIV-1 Infected Patients,”Biol. Chem., 1989; vol. 370: pp. 101-108.
Eck, et al., “Influence of the Extracellular Glutamate Concentration on the Intracellular Cyst(e)ine Concentration in Macrophages and on the Capacity to Release Cysteine,”Biol. Chem., 1989; vol. 370: pp. 109-113.
Hag, et al., “Immunomodulation by Neutrophil Myeloperoxidase and Hydrogen Peroxide: Differential Susceptibility of Human Lymphocyte Functions,”J. Immun., 1986; vol. 136, No. 9: pp. 3420-3426.
Fagan, et al., “Serum Levels of C-reactive Proteinin Crohn's Disease and Ulcerative Colitis,”Eur. J. Clin. Invest., 1982; vol. 12: pp. 351-359.
Fantone, et al., “Role of Oxygen-Derived Free Radicals and Metabolites in Leukocyte-dependent Inflammatory Reactions,”AJP, 1982; vol. 107, No. 3: pp. 397-418.
Fischman, et al., “Inhibition of Lectin-induced Lymphocyte Activation by 2-Cyclohexene-1-One: Decreased Intracellular Glutathione Inhibits an Early Event in the Activation Sequence,”J. Immun., 1981; vol. 127, No. 6: pp. 2257-2262.
Fraser, et al., “Turnover of Type II Collagen and Aggrecan in Cartilage Matrix at the Onset of Inflammatory Arthritis in Humans,”Arth. Rheum., 2003; vol. 48, No. 11: pp. 3085-3095.
Hamanaka, et al., “Protoprotective Effect on Topically Applied Superoxide Dismutase on Sunburn Reaction in Comparison with Sunscreen,”J. Derm., 1990; vol. 17: pp. 595-598.
Haverkate, et al., “Haemostasis Factors in Angina Pectoris; Relation to Gender, AGen and Acute-Phase Reaction,”Thromb. Haemost., 1995; vol. 73, No. 4: pp. 561-567.
Hebbel, et al., “Spontaneous Oxygen Radical Generation by Sickle Erythrocytes,”J. Clin. Invest., 1982; vol. 70: pp. 1253-1259.
Hernandez, et al., “Calcium Antagonists and Atherosclerosis Protection in Hypertension,”Amer. J. Therap., 2003; vol. 10: pp. 409-414.
Machiedo, et al., “Temporal Relationship of Hepatocellular Dysfunction and Ischemia in Sepsis,”Arch. Surg., 1988; vol. 123: pp. 424-427.
Kalebic, et al., “Suppression of Human Immunodeficiency Virus Expression in Chronically Infected Monocytic Cells by Glutathione, Glutathione Ester, andN-acetylcysteine,”Proc. Natl. Acad. Sci. USA, 1991; vol. 88: pp. 986-990.
Kar, et al., “Relative Efficacy of Three Medicinal Plant Extracts in the Lateration of Thyroid Hormone Concentrations in Male Mice,”J. Ethnopharm., 2002; vol. 81: pp. 281-285.
Kline, et al., “Vitamin E and Breast Cancer,”J. Nutr. 2004; vol. 134: pp. 3458S-3462S.
Koenig, et al., “C-Reactive Protein, a Sensitive Marker of Inflammation, Predicts Future Risk of Coronary Heart Disease in Initially Healthy Middle-Aged Men,”Circulation, 1999; vol. 99: pp. 237-242.
Kraut, et al., “The Effect of Oxidant Injury on the Lymphocyte Membrane and Functions,”J.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compositions for alleviating inflammation and oxidative... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions for alleviating inflammation and oxidative..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions for alleviating inflammation and oxidative... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3720619

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.