Compositions for affecting weight loss

Details Compositions for affecting weight loss Compositions for affecting weight loss

2008-05-20

2008-05-20

Kwon, Brian (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S649000, C514S321000

Reexamination Certificate

active

07375111

ABSTRACT:
Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is an opioid antagonist and the second compound causes increased agonism of a melanocortin 3 receptor (MC3-R) or a melanocortin 4 receptor (MC4-R) compared to normal physiological conditions. Also disclosed are methods of affecting weight loss, increasing energy expenditure, increasing satiety in an individual, or suppressing the appetite of an individual, comprising identifying an individual in need thereof and treating that individual to antagonize opioid receptor activity and to enhance α-MSH activity.

REFERENCES:
patent: 3819706 (1974-06-01), Mehta
patent: 3885046 (1975-05-01), Mehta
patent: 4089855 (1978-05-01), Chatterjie et al.
patent: 4172896 (1979-10-01), Uno et al.
patent: 4513006 (1985-04-01), Maryanoff et al.
patent: 4673679 (1987-06-01), Aungst et al.
patent: 4689332 (1987-08-01), McLaughin et al.
patent: 4855306 (1989-08-01), Markstein et al.
patent: 5312925 (1994-05-01), Allen et al.
patent: 5358970 (1994-10-01), Ruff et al.
patent: 5403595 (1995-04-01), Kitchell et al.
patent: 5426112 (1995-06-01), Zagon et al.
patent: 5427798 (1995-06-01), Ludwig et al.
patent: 5486362 (1996-01-01), Kitchell et al.
patent: 5512593 (1996-04-01), Dante
patent: 5541231 (1996-07-01), Ruff et al.
patent: 5719197 (1998-02-01), Kanios et al.
patent: 5731000 (1998-03-01), Ruff et al.
patent: 5763493 (1998-06-01), Ruff et al.
patent: 5817665 (1998-10-01), Dante
patent: 5856332 (1999-01-01), Dante
patent: 5958962 (1999-09-01), Cook
patent: 6004970 (1999-12-01), O'Malley et al.
patent: 6034091 (2000-03-01), Dante
patent: 6048322 (2000-04-01), Kushida
patent: 6071537 (2000-06-01), Shank
patent: 6071918 (2000-06-01), Cook
patent: 6110973 (2000-08-01), Young
patent: 6150366 (2000-11-01), Arenson et al.
patent: 6191117 (2001-02-01), Kozachuk
patent: 6197827 (2001-03-01), Cary
patent: 6210716 (2001-04-01), Chen et al.
patent: 6245766 (2001-06-01), Watsky
patent: 6248363 (2001-06-01), Patel et al.
patent: 6262049 (2001-07-01), Coffin et al.
patent: 6274579 (2001-08-01), Morgan et al.
patent: 6323236 (2001-11-01), McElroy
patent: 6344474 (2002-02-01), Maruani et al.
patent: 6369113 (2002-04-01), Young
patent: 6387956 (2002-05-01), Shapira
patent: 6437147 (2002-08-01), Anderson et al.
patent: 6441038 (2002-08-01), Loder et al.
patent: 6481031 (2002-11-01), Hwang
patent: 6506799 (2003-01-01), Dasseux
patent: 6541478 (2003-04-01), O'Malley et al.
patent: 6548551 (2003-04-01), Hinz
patent: 6569449 (2003-05-01), Stinchcomb et al.
patent: 6589553 (2003-07-01), Li et al.
patent: 6686337 (2004-02-01), Connor
patent: 6713488 (2004-03-01), Sadee et al.
patent: 6905708 (2005-06-01), Li et al.
patent: 7109198 (2006-09-01), Gadde et al.
patent: 2001/0025038 (2001-09-01), Coffin et al.
patent: 2002/0025972 (2002-02-01), Hintz
patent: 2002/0037836 (2002-03-01), Henriksen
patent: 2002/0090615 (2002-07-01), Rosen et al.
patent: 2002/0198227 (2002-12-01), Bernstein
patent: 2003/0055008 (2003-03-01), Marcotte
patent: 2003/0055038 (2003-03-01), Howard
patent: 2003/0130322 (2003-07-01), Howard
patent: 2003/0144174 (2003-07-01), Brenna et al.
patent: 2003/0144271 (2003-07-01), Shulman
patent: 2004/0002462 (2004-01-01), Najarian
patent: 2004/0029941 (2004-02-01), Jennings
patent: 2004/0033965 (2004-02-01), Gadde et al.
patent: 2004/0106576 (2004-06-01), Jerussi et al.
patent: 2004/0122033 (2004-06-01), Nargund et al.
patent: 2004/0158194 (2004-08-01), Wolff et al.
patent: 2004/0198668 (2004-10-01), Gadde et al.
patent: 2004/0242974 (2004-12-01), Glover
patent: 2004/0254208 (2004-12-01), Weber et al.
patent: 2005/0004106 (2005-01-01), Romano
patent: 2005/0026986 (2005-02-01), Maruani et al.
patent: 2005/0137144 (2005-06-01), Gadde et al.
patent: 2005/0143322 (2005-06-01), Gadde et al.
patent: 2005/0154002 (2005-07-01), Crooks et al.
patent: 2005/0181070 (2005-08-01), Gadde et al.
patent: 2005/0215552 (2005-09-01), Gadde et al.
patent: 2005/0277579 (2005-12-01), Krishnano et al.
patent: 2006/0009514 (2006-01-01), Gadde et al.
patent: 2006/0058293 (2006-03-01), Weber et al.
patent: 2006/0079501 (2006-04-01), Gadde et al.
patent: 2006/0100205 (2006-05-01), Weber et al.
patent: 2006/0122127 (2006-06-01), Rao et al.
patent: 2006/0142290 (2006-06-01), Weber et al.
patent: 2006/0160750 (2006-07-01), Gadde et al.
patent: 2007/0117827 (2007-05-01), Tollefson et al.
patent: 0 442 769 (1991-08-01), None
patent: 2214241 (1996-06-01), None
patent: WO 90/13294 (1990-11-01), None
patent: WO 94/20100 (1994-09-01), None
patent: WO 96/09047 (1996-03-01), None
patent: WO 99/37305 (1999-07-01), None
patent: WO 00/51546 (2000-09-01), None
patent: WO 00/76493 (2000-12-01), None
patent: WO 01/62257 (2001-08-01), None
patent: WO 03/013524 (2003-02-01), None
patent: WO 03/092682 (2003-11-01), None
patent: WO 03/097046 (2003-11-01), None
patent: WO 03/097046 (2003-11-01), None
patent: WO 2004/009015 (2004-01-01), None
patent: WO 2004/024096 (2004-03-01), None
patent: WO 2004/050020 (2004-06-01), None
patent: WO 2004/050020 (2004-06-01), None
patent: WO 2004/096201 (2004-11-01), None
patent: WO 2004/100992 (2004-11-01), None
patent: WO 2004/110368 (2004-12-01), None
patent: WO 2004/110375 (2004-12-01), None
patent: WO 2005/000217 (2005-01-01), None
patent: WO 2005/049043 (2005-06-01), None
patent: WO 2006/017504 (2006-02-01), None
“Approval Letter” of Application No. NDA 20-711, Department of Health & Human Services, May 14, 1997.
Zhang et al. “Positional cloning of the mouse obese gene and its humane homologue,”Nature372:425-432 (1994).
Devlin et al.Int. J. Eating Disord. 28:325-332 (2000).
Cone et al. “The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis,”Int'l Journal of Obesity, 25(5):S63-S67 (2001).
Saper et al. “The need to feed: Homeostatic and hedonic control of eating,”Neuron, 36:199-211 (2002).
Korner et al. “The emerging science of body weight regulation and its impact on obesity treatment,”J. Clin. Invest., 111(5):565-570 (2003).
Portoghese, P.S.J. Med. Chem., 35:1927 (1992).
Carroll, F.I.J. Med. Chem., 46:10 (2003).
Glass et al.Neuropeptides, 33:350 (1999).
Schmidhammer et al.A. Helv. Chim. Acta, 77:999 (1994).
Hahn et al.J. Pharm. Exper. Therapeutics, 235:846-850 (1985).
Kolb et al.A. Pharmaceutical Res., 6:266-271 (1985).
Pasternak et al.J. of Med. Chem., 23:674-676 (1980).
Le Bourdonnec et al.J. Med. Chem., 43:2489-2492 (2000).
Sayre et al.J. Med. Chem., 27:1325 (1984).
Erez et al.J. Med. Chem., 25:847-849 (1982).
Dechant et al.Drugs, 41:225-253 (1991).
Tamiz et al.J. Am. Chem. Soc., 122:5393-5394 (2000).
Tamiz et al.J. Med. Chem., 44:1615:1622 (2001).
Hussey et al.J. Am. Chem. Soc., 125:3692-3693 (2003).
Portoghese et al.Life Sci., 31:1283-1286 (1982).
Portoghese et al.J. Med. Chem., 29:1855-1861 (1986).
Stepinski et al.Internat. J. of Peptide&Protein Res., 38:588-592 (1991).
Parr et al.J. Immunol., 169:856-864 (2002).
Klok et al.Macromolecules, 35:746-759 (2002).
Portoghese et al.J. Med. Chem., 29:1650-1653 (1986).
Sashiwa et al.Macromolecules, 33:6913 (2000).
Ninan et al.Tetrahedron., 48:6709:16 (1992).
Zeng et al.Tetrahedron Lett., 29:5123 (1988).
Remington's Pharmaceutical Sciences. 18thEdition; Easton, PA: Mack Publishing Co. (1990).
Fingl et al.The Pharmacological Basis of Theraputics. Ch.1, pp. 1. (1975).
Spigset, et al.Therapeutic Approaches to Bulimia Nervosa, Expert Opinion on Therapeutic Patents, vol. 11, No. 3, 2001, pp. 463-477; XP002292382.
Islam, et al.Naltrexone, Serotonin Receptor Subtype Antagonists, and Carbohydrate Intake in Rats, Pharmacology Biochemistry and Behavior, vol. 48, No. 1, 1994, pp. 193-201; XP002292383.
Olszewski, et al.Evidence of Interactions Between Melanocortin and Opioid Systems in Regulation of Feeding, Neuroreort, vol. 12, No. 8, Jun. 13, 2001, pp. 1727-1730: XP009035026.
Zhu, et al.Pharmacologic Treatment of Easting Disorders, Canadian Journal of Psychiatry, vol. 47 No. 3, Apr. 3, 2002 pp. 227-234; XP009035028.
Werneke, et al.Options for Pharma

Affiliated with

Also associated with

Rating

Compositions for affecting weight loss does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions for affecting weight loss, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions for affecting weight loss will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2778899