Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Derived from mollusk
Reexamination Certificate
2008-06-17
2008-06-17
Davis, Ruth A (Department: 1651)
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Derived from mollusk
C424S400000, C424S489000, C424S520000
Reexamination Certificate
active
07387797
ABSTRACT:
Disclosed are compositions which include an isolated soft tissue fromModiolus modiolus(“MM”) and compositions which include an oil isolated from MM or a portion thereof. Also disclosed are methods of treating adenocarcinoma in a subject; methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells; methods of inhibiting the activity of 5-lipoxygenase or 12-lipoxygenase or both in cells; and methods of treating a subject suffering from a disease or condition associated with excessive 5-lipoxygenase activity or 12-lipoxygenase activity or both. A process for preparing an MM extract by contacting MM or a portion thereof with a solvent under conditions effective to extract one or more materials from the MM or portion thereof is also described.
REFERENCES:
patent: 4336247 (1982-06-01), Eriksen
patent: 5372937 (1994-12-01), Nilsson
patent: 6127166 (2000-10-01), Bayley et al.
patent: 6171626 (2001-01-01), Lagos et al.
patent: 6596303 (2003-07-01), Bui et al.
Farbu et al., “Ubiquinone analysis in fish tissues and in some marine invertabrates”, Comparative Biochemistry and Physiology B, 1979, vol. 63, No. 3, pp. 395-398, abstract.
Olafsen et al., Indigenous Bacteria in Hemolymph and Tissues of Marine Bivalves at Low Temperatures, Appl. Environ, Microbiology, 1993, 59:1848-1854.
Farbu et al., “Ubiquinone analysis in fish tissues and in some marine invertabrates”, Comp Biochem Physiol, vol. 638, p. 395-397, 1979.
Lebedev et al., “Specificity of Nitrogenous Extractive Compounds in Tissues of Metridium and Some Molluses,”Comp. Biochem. Physiol. A Comp. Physiol., 54(1):125-127 (1976), abstract only.
Bailey et al., “Regulation of T-Lymphocyte Mitogenesis by the Leukocyte Product 15-Hydroxy-Eicosatetraenoic Acid (15-HETE),”Cell. Immunol., 67(1):112-120 (1982).
Julshamn et al., “Subcellular Distribution of Major and Minor Elements in Unexposed Molluscs in Western Norway-III. Distribution and Binding of Cadmium, Zinc, Copper, Magnesium, Manganese, Iron and Lead in the Kidney and the Digestive System of the Horse Mussel Modiolus Modiolus,”Comp. Biochem. Physiol., 75A(1):17-20 (1983).
Smith et al., “Eicosanoid Effects on Cell Proliferation in Virto: Relevance to Atherosclerosis,”Prostaglandins Leukotrienes Med., 16:1-10 (1984).
Chan et al., “Leukotriene B4 and 12-Hydroxyeicosatetraenoic Acid Stimulate Epidermal Proliferation In Vivo in the Guinea Pig,”J. Invest. Dermatol., 85(4):333-334 (1985).
Kragballe et al., “Increased Aggregation and Arachidonic Acid Transformation by Psoriatic Platelets: Evidence That Platelet-Derived 12-Hydroxy-Eicosatetraenoic Acid Increases Keratinocyte Dna Synthesis In Vitro,”Arch. Dermatol. Res., 278(6):449-453 (1986).
Nadler et al., “Specific Action of the Lipoxygenase Pathway in Mediating Angiotensin II-Induced Aldosterone Synthesis in Isolated Adrenal Glomerulosa Cells,”J. Clin. Invest., 80(6):1763-1769 (1987).
Setty et al., “The Mitogenic Effect of 15- and 12-Hydroxyeicosatetraenoic Acid on Endothelial Cells May Be Mediated via Diacylglycerol Kinase Inhibition,”J. Biol. Chem., 262(36):17613-17622 (1987).
Bandyopadhyay et al., “Proliferative Effects of Insulin and Epidermal Growth Factor on Mouse Mammary Epithelial Cells in Primary Culture. Enhancement by Hydroxyeicosatetraenoic Acids and Synergism with Prostaglandin E2,”J. Biol. Chem., 263(16):7567-7573 (1988).
Nolan et al., “Role of Arachidonic Acid Metabolism in the Mitogenic Response of BALB/c 3T3 Fibroblasts to Epidermal Growth,”Mol. Parmacol., 33(6):650-656 (1988).
Funk et al., “Molecular Cloning, Primary Structure, and Expression of the Human Platelet/Erythroleukemia Cell 12-Lipoxygenase,”Proc. Natl. Adad. Sci. USA, 87(15):5638-5642 (1990).
Marnet et al., “Anachidonica Acid Metabolism of Cytosolic Fractions of Lewis Lung Carcinoma Cells,”Adv. Prostaglandin Thromboxane Leukotriene Res., 21:895-900 (1990).
Hada et al., “Catalytic Properties of Human Platelet 12-Lipoxygenase as Compared with the Enzymes of Other Origins,”Biochim. Biophys. Acta, 1083(1):83-93 (1991).
Rzepecki et al., “Molecular Diversity of Marine Glues: Polyphenolic Proteins From Five Mussel Species,”Molecular Marine Biology and Biotechnology, 1(1):78-88 (1991).
Skouteris et al., “Prostaglandins E2 and F2a Mediate the Increase in c-myc Expression Induced by EGF in Primary Rat Hepatocyte Cultures,”Biochem. Biophys. Res. Comm., 178(3):1240-1246 (1991).
De Marzo et al., “Cloning and Expression of an Airway Epithelial 12-Lipoxygenase,”Am. J. Physiol., 262(2 Pt. 1):L198-L207 (1992).
Funk et al., “Characterization of Human 12-Lipoxygenase Genes,”Proc. Natl. Adad. Sci. USA, 89(9):3962-3966 (1992).
Watanabe et al., “Molecular Cloning of a 12-Lipoxygenase cDNA from Rat Brain,”Eur. J. Biochem., 212(2):605-612 (1993).
Dethlefsen et al., “Arachidonic Acid Metabolites in bFGF-, PDGF-, and Serum-Stimulated Vascular Cell Growth,”Exp. Cell. Res., 212(2):262-273 (1994).
Lysz et al., “12(S)-Hydroxyeicosatetraenoic Acid Regulates DNA Synthesis and Protooncogene Expression Induced by Epidermal Growth Factor and Insulin in Rat Lens Epithelium,”Cell Growth Differ., 5(10):1069-1076 (1994).
Fesus et al., “Probing the Molecular Program of Apoptosis by Cancer Chemopreventive Agents,”J. Cell. Biochem. Suppl., 22:151-161 (1995).
Freire-Moar et al., “Cloning and Characterization of a Murine Macrophage Lipoxygenase,”Biochim. Biophys. Acta, 1254(1):112-116 (1995).
Lotan, “Retinoids and Apoptosis: Implications for Cancer Chemoprevention and Therapy,”J. Natl. Cancer Inst., 87(22):1655-1657 (1995).
van Zandwijk, “N-acetylcysteine (NAC) and Glutathione (GSH): Antioxidant and Chemopreventive Properties, with Special Reference to Lung Cancer,”J. Cell Biochem. Suppl., 22:24-32 (1995).
Database BIOSIS on STN, Accession No. 1976:172502 (1976) (Abstract only).
Database BIOSIS on STN, Accession No. 1983:326909 (1993) (Abstract only).
Database BIOSIS on STN, Accession No. 1995:126311 (1995) (Abstract only).
Database BIOSIS on STN, Accession No. 1994:97546142 (1994), entire document.
Carbon Isotope Compositions of Fatty Acids in Mussels from Newfoundland Estuaries,Estuarine, Coastal and Shelf Science, 39:261-272 (1994).
Adrian Thomas E.
Collin Peter D.
Creighton University
Davis Ruth A
Rogalskyj, Esq. Peter
LandOfFree
Compositions derived from Modiolus modiolus and methods... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions derived from Modiolus modiolus and methods..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions derived from Modiolus modiolus and methods... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2798319