Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic...
Patent
1996-05-10
1998-08-11
Mosley, Terressa
Drug, bio-affecting and body treating compositions
Topical body preparation containing solid synthetic organic...
A61K 3174
Patent
active
057924490
DESCRIPTION:
BRIEF SUMMARY
This invention concerns a composition containing zinc for the treatment of skin disorders.
Conventional zinc containing creams and ointments comprise zinc in the form of zinc oxide.
Zinc oxide is a form of zinc highly insoluble in water, lipids and non-polar solvents and is thus merely suspended in a pharmaceutical carrier to produce a white ointment or cream which is poorly absorbed into the skin leaving unsightly deposits on the skin after use.
The present invention overcomes, at least to some extent, the problems aforesaid.
According to the present invention there is provided a composition for the treatment of skin disorders comprising zinc linoleate and free linoleic acid in a pharmaceutically acceptable carrier.
Zinc linoleate is a colourless and fat soluble form of zinc which is readily absorbed into the skin.
Since it is known that slightly acidic compositions are better absorbed by the skin than neutral or alkaline preparations, free linoleic acid is included in the composition to adjust the pH of the composition to around pH 5.5.
The composition may comprise a zinc ion content of 0.1 to 8.5%, and preferably between 1 and 5%.
The composition may comprise a free linoleic acid content of 0.1 to 50%.
The composition may also comprise zinc oleate, zinc oxide, zinc salts of conjugated isomers of linoleic acid, water and an emulsifying agent.
The composition may also comprise an antioxidant, for example, vitamin E or vitamin A.
The composition may also comprise vitamin D.sub.3 or any other additive known to have properties beneficial to any skin condition.
The composition may be used topically to relieve the symptoms of a variety of skin conditions, for example, eczema, dermatitis, psoriasis, acne vulgaris, nappy rash.
The composition may also comprise an antibacterial constituent, for example, zinc iodate, potassium iodate, an iodophor or cetylpyrididium chloride. Such a composition is envisaged to be of particular use for the treatment of minor cuts and abrasions as well as more severe leg and other cutaneous ulcers.
The composition may also comprise a minor proportion of copper ions, preferably in the form of copper linoleate.
The composition may also comprise a local anaesthetic, for example, lignocaine. Such a preparation would give rapid symptomatic relief of itching and/or pain.
The pharmaceutically acceptable carrier may comprise emulsifying ointment BP or any other suitable carrier, for example, soft/hard paraffin.
The composition may be applied topically to the skin in the form of a cream or ointment, or via a pad or bandage pre-soaked in the composition, or by any other mode of administration capable of delivering an effective amount of composition to the site of injury.
The composition may vary in consistency from a cream to an ointment by varying its water content.
It is envisaged that a zinc linoleate cream according to the present invention may be used in cosmetics and sunscreen lotions.
According to a second aspect of the invention there is provided a method of manufacture of a composition for the treatment of skin disorders comprising zinc linoleate and free linoleic acid in a pharmaceutically acceptable carrier.
A method of manufacture may comprise mixing zinc oxide in a suitable carrier, for example, emulsifying ointment BP, adding linoleic acid and heating with stirring to a temperature sufficient to convert essentially all the zinc oxide into zinc linoleate whilst leaving sufficient free linoleic acid to maintain a slightly acidic pH of the composition upon cooling.
An example of this method of manufacture of the composition of the present invention comprises stirring together 15 g zinc oxide with 250 g emulsifying ointment BP and warming until fluid. 227 ml of linoleic acid is then stirred into the mixture which is heated to 70.degree. C. until the liquid turns pale yellow and is only slightly turbid. The mixture is then left to cool with stirring to give the composition of the present invention.
The linoleic acid used may not be pure linoleic acid but may comprise 68% linoleic acid
Kappa Pharmaceuticals Limited
Mosley Terressa
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