Compositions containing substituted aminobenzoates and use there

Details Compositions containing substituted aminobenzoates and use there Compositions containing substituted aminobenzoates and use there

1985-01-16

1986-12-16

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514826, A61K 3124

Patent

active

046297359

ABSTRACT:
Novel lower-alkyl 2-(hydroxyphenylamino)benzoates, useful as inhibitors of lipoxygenase, are of the formula ##STR1## wherein R is hydrogen, lower-alkyl or lower-alkoxy; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and Alk is lower-alkyl. The compounds are prepared by de-etherification of the corresponding alkyl or benzyl ethers.

REFERENCES:
patent: 3819637 (1974-06-01), Bell
Kim, J. Heterocyclic Chem. 18, 287, (1981), pp. 287-291.
Molnar et al., Helv. Chim. Acta 52, 401-408, (1969).
Legrand et al., Bull. Soc. Chim. France 1969, 1173-82.

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