Drug – bio-affecting and body treating compositions – Anti-perspirants or perspiration deodorants
Reexamination Certificate
2000-03-29
2002-06-04
Dodson, Shelley A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Anti-perspirants or perspiration deodorants
C424S066000, C424S067000, C424S068000, C424S400000, C424S401000
Reexamination Certificate
active
06399049
ABSTRACT:
FIELD OF INVENTION
This invention relates to compositions comprising solubilized antiperspirant active and selected polyol liquids defined by ClogP values and defined numbers and arrangements of attached hydroxyl groups. These compositions provide improved mildness, cosmetics and antiperspirant efficacy as compared to many other polyol-containing antiperspirant compositions, and can provide an improved means for formulating compositions containing solubilized antiperspirant active.
BACKGROUND OF THE INVENTION
Polyol-containing carriers and solvents are well known for use in topical antiperspirant compositions. These carriers are most typically used to solubilize the antiperspirant active or as coupling agents during the manufacturing process. These polyol carriers are typically aliphatic polyhydric alcohols which have from 2 to 12 carbon atoms, examples of which include ethylene glycol, diethylene glycol, butylene glycol (1,3-butane-diol), 1,2-propylene glycol, 1,3-propylene glycol, glycerine (1,2,3-trihydroxy propane), 2-methyl-2,4-pentane-diol (hexylene glycol), 2-ethyl-1,3-hexane-diol, 1,2,6-hexanetriol, 1,2,4-butanetriol, and combinations thereof.
Polyol-containing carriers are especially useful in formulating clear or translucent antiperspirant compositions. These compositions are typically anhydrous systems containing solubilized antiperspirant active, wherein the polyol carrier is used to help solubilize the active and in most cases provides the primary carrier material within which the solubilized active is miscible or dispersed within.
Many polyol-containing carriers, however, can cause skin irritation when topically applied to the underarms or other sensitive areas of the skin. This skin irritation is especially problematic when the applied composition is an anhydrous system containing higher concentrations of the polyol carrier. These higher polyol concentrations are often necessary in anhydrous antiperspirant compositions to successfully couple product gellants, structurants, thickening agents or other similar materials with other product carriers or solvents. This skin irritation, especially when caused by higher polyol concentrations, is especially problematic in a small percentage of the population that is unusually sensitive to topical polyol irritation. Although this type of skin irritation can be minimized by adding lower irritation solvents such as mineral oil or volatile silicones, these low irritation solvents are not miscible with higher concentrations of short carbon chain, highly polar, polyol solvents, e.g., dipropylene glycol, glycerin.
One recent attempt at providing improved polyol-containing carriers for use in now U.S. Pat. No. 5,968,489 antiperspirant products is described in U.S. patent application Ser. No. 09/071,178 (Swaile et al.) filed Jul. 27, 1999. The Swaile et al. Application discloses antiperspirant compositions containing 1,2-hexanediol, and the use of such compositions to provide improved mildness, cosmetics and antiperspirant efficacy.
It has now been found that polyol-containing carriers other than 1,2-hexanediol can also be selected for use in antiperspirant compositions which provide improved mildness, cosmetics and antiperspirant efficacy, provided that the selection is limited to those liquid polyols having adjacent hydroxy-substituted carbon atoms at the &agr; and &bgr; positions of the liquid polyol but not more than 4 adjacent hydroxy-substituted carbon atoms in the liquid polyol, wherein the hydroxy-substituted carbon at the &bgr; position also has attached a second group selected from an amide, ester, alkyl, ether or silicone wherein the second group contains at least 3 adjacent atoms selected from the group consisting of carbon, non-hydroxy oxygen, nitrogen, silicone and combinations thereof. The liquid polyol must have a C log P value of from about −4.0 to about 2.0, preferably a ClogP value of less than about 2.0, and the mole ratio of the liquid polyols to the antiperspirant metal ions (e.g., aluminum, zirconium) is preferably at least about 2.0. It has also been found that these polyol-containing carriers are especially effective in providing a suitable means for providing intermediate and finished antiperspirant products with solubilized antiperspirant active.
It also been found that the selection of the liquid polyols as defined by ClogP values provides the selected polyol with optimal active release characteristics at the appropriate time after topical application to the underarm. It has been found that the active release characteristics such as that provided by the selected polyols helps provide the composition with improved antiperspirant efficacy.
SUMMARY OF THE INVENTION
The present invention is directed to antiperspirant compositions, and corresponding methods of application, which compositions comprise from about 0.1% to about 50% by weight of solubilized antiperspirant active; and from about 0.1% to about 99.9% by weight of a liquid polyol having adjacent hydroxy-substituted carbon atoms at the &agr; and &bgr; positions of the liquid polyol but not more than 4 adjacent hydroxy-substituted carbon atoms in the liquid polyol, wherein the liquid polyol conforms to the formula:
wherein R is an amide, ester, alkyl, ether or silicone and contains at least 3 adjacent atoms selected from the group consisting of carbon, non-hydroxy oxygen, nitrogen, silicone and combinations thereof, and wherein the liquid polyol has a C log P value of from about −4.0 to about 2.0. The mole ratio of the liquid polyols to the antiperspirant metal ions (e.g., aluminum and zirconium) is preferably at least about 2.0.
It has been found that these antiperspirant compositions, and corresponding methods of application provide improved antiperspirant efficacy, cosmetics, and are milder to the skin, provided that the liquid polyol is selected to have the requisite number and arrangement of hydroxyl groups, and provided that the liquid polyol also has a ClogP value of less than about 2.0 and is used in the requisite mole ratio relative to the antiperspirant metal ions in the composition.
DETAILED DESCRIPTION
The antiperspirant compositions of the present invention include antiperspirant compositions in final, intermediate, or base forms, and include product forms such as solids or gel solid sticks, soft solids or creams, lotions or other liquids, aerosol or pump sprays, solutions or dispersions, and so forth. These antiperspirant compositions are intended for topical application to the underarm or other suitable area of the skin, or for formulation into topical underarm products that are likewise intended for similar application.
The term “anhydrous” as used herein, unless otherwise specified, characterizes the water content of the compositions and corresponding ingredients of the present invention, and means that these compositions and ingredients so characterized contain less than about 20%, more preferably less than about 10%, even more preferably less than about 5%, even more preferably less than about 3%, most preferably zero percent, by weight water.
The term “ambient conditions” as used herein refers to surrounding conditions under about one atmosphere of pressure, at about 50% relative humidity, and at about 25° C.
The term “volatile” as used herein refers to those materials which have a measurable vapor pressure as measured at 25° C. Such vapor pressures will typically range from about 0.01 mmHg to about 6 mmHg, more typically from about 0.02 mmHg to about 1.5 mmHg, and have an average boiling point at one atmosphere of pressure (1 atm) typically less than about 250° C, more typically less than about 235° C., at 1 atmosphere (atm) of pressure.
The term “aluminum and zirconium” as used herein, unless otherwise specified, means aluminum, or it means the combination of aluminum and zirconium in those embodiments optionally containing zirconium.
The term “metal” as used herein, unless otherwise specified, means the combination of aluminum and optional zirconium in the anhydrous composition of the present invention.
All percent
Hayes Fred Joseph
Hilvert Jennifer Elaine
Motley Curtis Bobby
Swaile David Frederick
The Procter & Gamble & Company
Winter William J.
LandOfFree
Compositions containing solubilized antiperspirant active does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions containing solubilized antiperspirant active, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions containing solubilized antiperspirant active will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2953947