Compositions containing protease produced by vibrio and method o

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases

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435220, 435909, A61K 3754

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active

051456818

ABSTRACT:
Compositions and methods of use are provided for debriding and wound healing applications. The compositions contain certain proteases produced by microorganisms of the genus Vibrio.

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patent: 4329430 (1982-05-01), Klein et al.
patent: 4668228 (1987-05-01), Bolton et al.
patent: 4865983 (1989-09-01), Durham
Merkel et al., "Proteolytic Activity and General Characteristics of a Marine Bacterium, Aeromonas Proteolytica SP. N.," Journal of Bacteriology (1964) 87:1227-1233.
Prytz et al., "Digestion of Human Burn Eschar by Proteolytic Enzymes," Enzymalia (1965) 28:367-376.
Boxer et al., "Debridement of Dermal Ulcers and Decubiti with Collagenese," Geriatrics (1969) 75-86.
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Shakespeare et al., "The Activity of the Enzymatic Debridement Agent Travase towards a Variety of Protein Substrates," Burns (1978) 6:15-20.
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