Compositions containing prodrugs of florfenicol and methods...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

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Details

C514S242000, C514S247000, C514S256000, C514S275000, C514S352000

Reexamination Certificate

active

07439268

ABSTRACT:
The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples of suitable prodrugs include one or a combination of one or a combination of the following: florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol hexanoate, florfenicol heptanoate, florfenicol octanoate, florfenicol nanoate, florfenicol decanoate, florfenicol undecanoate, florfenicol dodecanoate, and florfenicol phthalate. In another embodiment the prodrug is converted into the florfenicol in vivo by the action of one or more endogenous esterases. The invention also provides new compounds, pharmaceutical compositions containing the compounds, and methods for their administration.

REFERENCES:
patent: 4235892 (1980-11-01), Nagabhushan
patent: 4311857 (1982-01-01), Nagabhushan
patent: 4361557 (1982-11-01), Nagabhushan
patent: 4382892 (1983-05-01), Hayakawa et al.
patent: 4872411 (1989-10-01), Nagy
patent: 4876352 (1989-10-01), Schumacher et al.
patent: 5082863 (1992-01-01), Apelian et al.
patent: 5158948 (1992-10-01), Schoenleber et al.
patent: 5336664 (1994-08-01), Camaggi et al.
patent: 5352832 (1994-10-01), Wu et al.
patent: 5382673 (1995-01-01), Clark et al.
patent: 5663361 (1997-09-01), Towson et al.
patent: 5723447 (1998-03-01), Macy et al.
patent: 5756506 (1998-05-01), Copeland et al.
patent: 5866549 (1999-02-01), Or et al.
patent: 5958888 (1999-09-01), Macy et al.
patent: 5977133 (1999-11-01), Fung et al.
patent: 6239112 (2001-05-01), Macy et al.
patent: 6660278 (2003-12-01), Larsson et al.
patent: 6710068 (2004-03-01), LaColla et al.
patent: 2002/0065198 (2002-05-01), Highsmith et al.
patent: 2004/0082553 (2004-04-01), Boojamra et al.
patent: 2004/0198704 (2004-10-01), Shuster et al.
patent: WO 0241899 (1988-01-01), None
Bundgaard. Design of prodrugs, pp. 7-9, 21-24, Elseiver, Amsterdam, 1985.
A. D. Tuddle et al., “Bone Marrow Hypoplasia Secondary to Florfenicol Toxicity in a Thomson's Gazelle” (Gazella thomsonii), Journal of Veterinary Pharmacology and Therapeutics, vol. 29, pp. 317-319 (Aug. 2006).
R.H.C. Penny et al., “Effects of Chloramphenicol on the Haemopoietic System of the Cat,” British Veterinary Journal, vol. 123, pp. 145-153 (1967).
A.D.J. Watson, “Further Observations on Chloramphenicol Toxicosis in Cats,” American Journal of Veterinary Research, vol. 41, pp. 293-294 (Feb. 1980).

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