Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1990-10-02
1993-04-13
Lacey, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303871, 5303881, 424 858, 424 8591, 435 696, 435 7021, 4351722, 4351723, 43524027, 4352523, 4353201, 935 93, 935100, 935104, 935107, C07K 1528, A61K 39395, C12N 1513
Patent
active
052024229
ABSTRACT:
The present invention contemplates glycopolypeptide multimers having a polypeptide that contain an immunoglobulin amino acid residue sequence and an oligosaccharide that comprises a core pentasaccharide and N-acetylglucosamine-containing outer branches, such that the multimer is free from sialic acid. The production of passive immunity in an animal by administering a sialic acid free glycopolypeptide multimer is also contemplated. In addition, the invention describes a method for producing a glycopolypeptide multimer by introducing first and second mammalian genes encoding the constituent parts of the multimer into first and second respective members of a plant species, generating a progeny from the first and second plant species members, and isolating the glycopolypeptide multimer from the progeny plant.
REFERENCES:
patent: 4762785 (1988-08-01), Comai
patent: 4771002 (1988-09-01), Gelvin
patent: 4956282 (1990-09-01), Goodman et al.
During, et al., Plant Molecular Biology, 15: 281-293, "Synthesis and Self-Assembly of a Functional Monoclonal Antibody in Transgenic Nicotiana tabacum", (1990).
Azipurua et al., J. Exp. Med., 167:440-451 (1988).
Hiatt et al. "Production of Antibodies in Transgenic Plants", Nature 343:76-78, Nov. 2, 1989.
Thorens et al., "Chloroquine and Ammonium Chloride Prevent Terminal Glycosylation of Immunoglobulins in Plasma Cells Without Affecting Secretion", Nature 321:618-620, 1986.
Edelman et al., "The Covalent Structure of an Entire .gamma.G Immunoglobulin Molecule", Proc. Nat. Acad. Sci. USA 63:78-85, 1969.
Hein Mich B.
Hiatt Andrew C.
Bingham Douglas A.
Budens Robert D.
Fitting Thomas
Lacey David L.
Logan April C.
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