Compositions containing nucleic acids and ligands for therapeuti

Details Compositions containing nucleic acids and ligands for therapeuti Compositions containing nucleic acids and ligands for therapeuti

1996-09-24

2000-03-14

Priebe, Scott D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 231, 424 9321, 435 691, 4353201, 435325, 435455, 435458, 530350, A61K 4800, A01N 6300, C12N 1500

Patent

active

060373296

ABSTRACT:
Preparations of conjugates of a receptor-binding internalized ligand and a cytocide-encoding agent and compositions containing such preparations are provided. The conjugates contain a polypeptide that is reactive with an FGF receptor, such as bFGF, or another heparin-binding growth factor, cytokine, or growth factor coupled to a nucleic acid binding domain. One or more linkers may be used in the conjugation. The linker is selected to increase the specificity, toxicity, solubility, serum stability, or intracellular availability, and promote nucleic acid condensation of the targeted moiety. The conjugates are complexed with a cytocide-encoding agent, such as DNA encoding saporin. Conjugates of a receptor-binding internalized ligand to a nucleic acid molecule are also provided.

REFERENCES:
patent: 5166320 (1992-11-01), Wu et al.
patent: 5169933 (1992-12-01), Anderson et al.
patent: 5308622 (1994-05-01), Casscells et al.
patent: 5354844 (1994-10-01), Beug et al.
patent: 5521291 (1996-05-01), Curiel et al.
patent: 5635383 (1997-06-01), Wu et al.
patent: 5679637 (1997-10-01), Lappi et al.
patent: 5707969 (1998-01-01), Nabel et al.
patent: 5830686 (1998-11-01), Henderson
Sosnowski et al., "Targeting DNA through fibroblast growth factor receptors," Proceedings of the American Association for Cancer Research 37: 426, Abstract No. 2911, Mar. 1996.
Sosnowski et al., "Receptor Mediated Gene Delivery Through the FGF Receptor: Applications in the Eye," Investigative Ophthalmology & Visual Science 37(3):S187, Abstract No. 885, 1996.
Chen et al., "A novel gene delivery system using EGF receptor-mediated endocytosis," FEBS Letters 338: 167-169, 1994.
Chen et al., "Design of a genetic immunotoxin to eliminate toxin immunogenicity," Gene Therapy 2: 116-123, 1995.
Dauchel et al., "Modulation of Mitogenic Acitivity and Cellular Binding of Basic Fibroblast Growth Factor by Basic Proteins," Journal of Cellular Biochemistry 39: 411-420, 1989.
Fattom et al., "Comparative Immunogenicity of Conjugates Composed of the Staphylococcus aureus Type 8 Capsular Polysaccharide Bound to Carrier Proteins by Adipic Acid Dihydrazide or N-Succinimidyl-3-(2-Pyridyldithio) propionate," Infection and Immunity 60(2): 584-589, 1992.
Hoganson et al., "Comparison of the Effects of Three Different Toxin Genes and Their Levels of Expression on Cell Growth and Bystander Effect in Lung Adenocarcinoma," Cancer Research 56: 1315-1323, 1996.
Wagner et al., "Transferrin-polycation conjugates as carriers for DNA uptake into cells," Proc. Natl. Acad. Sci. USA 87: 3410-3414, 1990.
Westby et al., "Separation and Characterization of Recombinant Proricin Containing an Alternative Protease-Sensitive Linker Sequence," Bioconjugate Chem. 3: 375-381, 1992.
Zenke et al., "Receptor-mediated endocytosis of transferrin-polycation conjugates: An efficient way to introduce DNA into hematopoietic cells," Proc. Natl. Acad. Sci. USA 87: 3655-3659, 1990.
Dauchel et al. (J. Cell. Biol. 39, 4, pp. 411-420, 1989).
Vile et al. (Molecular Medicine Today, vol. 4, 2:84-92, 1998).
Deonarain et al. (British J. Cancer, 70 (5):786-94), 1994).
Thorpe et al. (Cancer Res. 47, 592-5931, 1987).
Stein et al. (Mol. Cell Biol. 14(5):339203402, 1994).
Kreitman et al. (P.N.A.S., vol. 91, pp. 6889-6893, 1994).
Melton et al. (J. Natl. Cancer Inst., 88(3/4):153-165, 1996).
Bicknell, Analls of Oncology 5, Suppl. 4, S45-S50.
Rieck et al., Retinal Cell Biology/Cornea, Abstract No. 16823.
Ngo et al., The protein folding problem and tertiary structure function, Birkhauser Boston Inc., 14, 491-495, 1994.
Crystal, Science, vol. 270, 404-410, 1995.
Ledley (1995) Hum. Gene Ther. 6:1129-44.
Mastrangelo et al., Seminars in Oncology, vol. 23, 1: 4-21, 1996.
Coglan (Nov. 1995) New Scientist, pp. 14-15.
Gunzberg et al., Mol. Medicine Today, 1995, 4: pp. 410-417.

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