Compositions containing non-glycosylated human tissue type plasm

Details Compositions containing non-glycosylated human tissue type plasm Compositions containing non-glycosylated human tissue type plasm

1991-08-06

1994-10-04

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 941, 424 943, 435188, A01K 3748, A01K 3762, A01K 37547, C12N 996

Patent

active

053524535

ABSTRACT:
Pharmaceutical compositions containing non-glycosylated human tissue type plasminogen activator (t-PA) having enzymatic activity of at least 0.1 MU/ml are disclosed. The compositions have a pH of from 4.5 to 6, contain citrate, and at least one other compound.

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patent: 4985245 (1991-01-01), Kakimoto et al.
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Larsen, G. R., et al., "Blood," vol. 73(7), Mar. 15, 1989, pp. 1842-1850.
Martin. U., et al., "Thrombosis Research," vol. 62(3), 1991, pp. 137-146.
Celley, R. F.; et al., "Biochemistry," vol. 8, 1989, pp. 4047-4054.

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