Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
2000-06-29
2003-11-18
Padmanabhan, Sreeni (Department: 1617)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C514S452000, C514S546000, C514S554000, C514S556000, C514S560000
Reexamination Certificate
active
06649176
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to a cosmetic composition comprising mineral water and one or more compounds selected from the group consisting of creatine, pyruvic acid, and carnitine, and cosmetically acceptable salt or ester thereof.
BACKGROUND OF THE INVENTION
Cosmetic compositions containing mineral water, e.g., in the form of liposomes, have been reported for the purpose of hydrating the skin. See French Patent Applications 2,608,426 and 2,668,063. Others have reported the use of mineral water in cosmetic compositions to reduce the irritant side effects of active agents such as salicylic acid. See U.S. Pat. Nos. 5,690,946 and 5,997,885.
Carnitine is an amino acid that is synthesized endogenously in the liver from its amino acid precursors lysine and methionine. This water soluble amino acid is found in highest concentrations in the adrenal glands, skeletal, and cardiac muscle, and smaller concentrations are found in the kidneys and brain. This distribution of carnitine in the body reflects the utilization of fatty acids by the tissues as a source of energy. Carnitine functions as a biocatalyst to carry long and medium length chain fatty acids across the cell wall and into the mitochondria where fats are metabolized for energy production. The absence of proper levels of carnitine in the cells may result in poor metabolism of fatty acids which can cause buildup within the cell and its surroundings to eventually lead to elevated blood fat and triglyceride levels. During the last decade, carnitine has seen increase use for muscle efficiency since fatty acid oxidation within the mitochondria is the muscle's major source of energy. Carnitine is also used to improve fat metabolism and to reduce blood triglycerides. See, e.g., Bremer, J. “Carnitine, Metabolism and Functions” Physiology Review. 63:1420-1480 (1983); Opie, L. H. “Role of Carnitine in Fatty Acid Metabolism of Normal and Ischemic Myocardium”, Am. Heart Journal, 3:375-377 (1974); and Stryer, L. “Biochemistry”, 3
rd
ed., (1988, W. H. Freeman and Company, New York).
Creatine is synthesized in the liver and is supplemented by a diet of meat and fish. Ninety-five percent of the body's creatine supply is found in the skeletal muscles. Creatine, which is converted into creatine phosphate within cells, increases the availability of energy to the cell in the form of adenosine triphosphate (ATP). Cells rely on energy produced in the Krebs cycle from the dephosphorylation of ATP to adenosine diphosphate (ADP). Creatine phosphate can then donate a phosphate group to ADP, recreating ATP and, thus, extending the energy generating biochemical pathways within cells. See, e.g. Balsom, P. D., et al. “Creatine in humans with special reference to creatine supplementation”, Sports-Med., 18(4):268-280 (1994) and Stryer, L. “Biochemistry”, 3
rd
ed., 1988, W. H. Freeman and Company, New York.
Pyruvate, the key glycolytic intermediate of all mammalian cells, is created during the metabolism of carbohydrates and protein. In addition to being formed in the body, pyruvate is present in foods including red apples, cheese, and red wine. The oxidation of pyruvate in the Krebs cycle provides cells with the bulk of adenosine triphosphate (ATP) used to maintain homeostasis. In cells with high energy charge, coenzyme A (CoA) is acylated as acetyl-CoA which activates pyruvate carboxylase, directing pyruvate toward gluconeogenesis. However, when energy is low in the cell, CoA is not acylated and pyruvate is preferentially oxidized via pyruvate dehydrogenase to CO
2
and H
2
O. Through its role as an energy source pyruvate has been suggested to aid weight loss efforts and exercise endurance. See, e.g., Stanko, R. T., Tietze, D. L., and Arch, J. E. “Body composition, energy utilization, and nitrogen metabolism with a 4.25-MJ/d low-energy diet supplemented with pyruvate,” Am J Clin Nutr, 56(4), 630-635 (1992) and Stryer, L. “Biochemistry”, 3
rd
ed.(1988, W. H. Freeman and Company, New York).
SUMMARY OF THE INVENTION
In one aspect, the invention features a cosmetic composition comprising mineral water and one or more compounds selected from the group consisting of creatine, carnitine, and pyruvic acid, and cosmetically acceptable salts thereof, wherein the mineral water has a mineralization of at least about 200 mg/L (e.g., from about 300 mg/L to about 1000 mg/L).
In one embodiment, the invention features a topical cosmetic composition comprising (i) mineral water, (ii) a compound selected from the group consisting of creatine, carnitine, and pyruvic acid, and a cosmetically acceptable salt or ester thereof, and (iii) a cosmetically-acceptable topical carrier, wherein the mineral water has a mineralization of at least 200 mg/L.
In one embodiment, the composition further comprises at least one nutrient or a skin-conditioning agent selected from the group consisting of an emollient and a humectant.
In one embodiment, the invention also features methods of topically administering such compositions. The compositions of the present invention can enhance the uptake of oxygen, water, and nutrients into the skin (e.g., skin cells), enhance skin cell metabolism, reduce the loss of skin firmness and elasticity, and/or have a reduced incidence of eye irritation.
REFERENCES:
patent: 3755560 (1973-08-01), Dickert et al.
patent: 4254105 (1981-03-01), Fukuda
patent: 4320145 (1982-03-01), Cavazza
patent: 4421769 (1983-12-01), Dixon et al.
patent: 4960764 (1990-10-01), Figueroa, Jr. et al.
patent: 4961927 (1990-10-01), Kogure
patent: 5106624 (1992-04-01), Bertini
patent: 5376379 (1994-12-01), Fabre et al.
patent: 5531993 (1996-07-01), Griat
patent: 5536751 (1996-07-01), Bunger
patent: 5578312 (1996-11-01), Parrinello
patent: 5580902 (1996-12-01), Yu et al.
patent: 5627212 (1997-05-01), Cavazza et al.
patent: 5637305 (1997-06-01), Cavazza et al.
patent: 5641814 (1997-06-01), Martin
patent: 5690946 (1997-11-01), Koulbanis et al.
patent: 5756107 (1998-05-01), Hahn et al.
patent: 5759610 (1998-06-01), Nishimoto et al.
patent: 5821237 (1998-10-01), Bissett et al.
patent: 5928657 (1999-07-01), Simon
patent: 5932234 (1999-08-01), Simon et al.
patent: 5935636 (1999-08-01), Nishimoto et al.
patent: 5951990 (1999-09-01), Ptchelintsev
patent: 5997885 (1999-12-01), Koulbanis et al.
patent: 6033684 (2000-03-01), Norcia
patent: 6086789 (2000-07-01), Brunengraber et al.
patent: 6106846 (2000-08-01), Breton et al.
patent: 6432424 (2002-08-01), Shapiro et al.
patent: 0 413 528 (1991-02-01), None
patent: 0 573 465 (1993-12-01), None
patent: 0 600 730 (1994-06-01), None
patent: 0273202 (1995-06-01), None
patent: 0559502 (1996-03-01), None
patent: 0 711 543 (1996-05-01), None
patent: 0 717 984 (1996-06-01), None
patent: 0699432 (1997-01-01), None
patent: 0773012 (1997-11-01), None
patent: 0 868 916 (1998-10-01), None
patent: 0846462 (1999-12-01), None
patent: 0 974 342 (2000-01-01), None
patent: 0 983 727 (2000-03-01), None
patent: 0 998 914 (2000-05-01), None
patent: 1248192 (1960-01-01), None
patent: 3574 (1964-05-01), None
patent: 2619007 (1989-02-01), None
patent: 2627385 (1989-08-01), None
patent: 2777778 (1998-04-01), None
patent: WO 84/04885 (1984-12-01), None
patent: WO 89/06958 (1989-08-01), None
patent: WO 95/03028 (1995-02-01), None
patent: WO 95/04537 (1995-02-01), None
patent: WO 95/13793 (1995-05-01), None
patent: WO 95/27501 (1995-10-01), None
patent: WO 96/11572 (1996-04-01), None
patent: WO 97/15282 (1997-05-01), None
patent: 99/07388 (1998-07-01), None
patent: 99/08681 (1998-08-01), None
patent: WO 98/51277 (1998-11-01), None
patent: WO 00/04870 (2000-02-01), None
West Database 1999-622294, Dumain et al., Cosmetic Products Containing Minerlized Water, (Oct. 1999), abstract of FR 2777778A1.*
EPO Search Report Dated Nov. 17, 2000 for European Patent Application No. 00307067.9, Pending USSN.
U.S. patent application Ser. No. 09/606,490, Johnson & Johnson Consumer Companies, Inc, Pending USSN.
U.S. patent application Ser. No. 09/607,118, Johnson & Johnson Consumer Companies, Inc, Pending USSN.
U.S. patent application Ser. No. 09/606,889, Johnso
Kaminski Claudia K.
Shapiro Stanley S.
Shaya Steven A.
Campagne Jean-Michel
Johnson & Johnson Consumer Companies Inc.
McGowan William E.
Padmanabhan Sreeni
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