Compositions containing leptin

Details Compositions containing leptin Compositions containing leptin

2008-02-20

2010-10-05

Landsman, Robert (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S351000, C436S023000

Reexamination Certificate

active

07807643

ABSTRACT:
A method and composition for administering leptin to a subject. The invention includes suspending isolated native leptin-containing milk fat globules in a suitable medium for administering to a subject. The suspended milk fat globules may be administered orally as well as by intravenous, intramuscular, intraperitone41, other enteral routes of administration, and other parenteral routes of administration. The invention includes a method for treating growth or maturational-related disorders in newborns as, well as subjects having conditions that can be treated by the administration of leptin.

REFERENCES:
patent: 4994496 (1991-02-01), Repasky et al.
patent: 5298246 (1994-03-01), Yano et al.
patent: 5552522 (1996-09-01), DiMarachi et al.
patent: 5552523 (1996-09-01), Basinski et al.
patent: 5552524 (1996-09-01), Basinski et al.
patent: 5756461 (1998-05-01), Stephens
patent: 5773416 (1998-06-01), Chehab
patent: 5789198 (1998-08-01), Akerblom
patent: 5795909 (1998-08-01), Shashoua et al.
patent: 5830450 (1998-11-01), Lallone
patent: 5866547 (1999-02-01), Flier et al.
patent: 5874535 (1999-02-01), Bailleul et al.
patent: 5882860 (1999-03-01), Snodgrass et al.
patent: 5942540 (1999-08-01), Kozachuk
patent: 6022737 (2000-02-01), Niven et al.
Smith-Kirwin, Leptin expression in human mammary epithelial cells and breast milk, 1998, The Journal of Clinical Endocrinology and Metabolism, vol. 83, Issue 5, pp. 1810-1813.
“Serum leptin concentrations in infants: effects fo diet, sex, and adiposity” by Bo Lonnerdal and Peter J. Havel; American Journel Clinical Nutrition 2000: 72: pp. 484-489.
Crawford et al, “Essential Fatty Acid Requirements in Infancy”,The American Journal of Clinical Nutrition,vol. 31, pp. 2181-2185, Dec. 1978.
Dukas et al, “Quantitation of Changes in the Expression of Multiple Genes by Simultaneous Polymerase Chain Reaction”,Analytical Biochemistry,vol. 215, pp. 66-72, 1993.
Gomm et al, “Separated Human Breast Epithelial and Myoepithelial Cells Have Different Growth Factor Requirements In Vitro But Can Reconstitute Normal Breast Lobuloalveolar Structure”,Journal of Cellular Physiology,vol. 117, pp. 11-19, 1997.
Halaas et al, “Physilogical Response to Long-term Peripheral and Central Leptin Infusion in Lean and Obese Mice”,Proc. Natl. Acad. Sci. USA,vol. 94, pp. 8878-8883, Aug. 1997.
Murphy et al, “Long-Term Correction of Obesity and Diabetes in Genetically Obese Mice by a Single Intramuscular Injection of Recombinant Adeno-Associated Virus Encoding Mouse Leptin”,Proc. Natl. Acad. Sci. USA,vol. 94, pp. 13921-13926, Dec. 1997.
Hamosh et al, “Lipids in Milk and the First Steps in Their Digestion”,Pediatrics,vol. 75 (suppl.), 1984, pp. 146-150.
Guisez et al, “Efficient Secretion of Biologically Active Recombinant OB Protein (Leptin) InEscherichia coli,Purification from the Periplasm and Characterization”,Protein Expression and Purification,vol. 12, pp. 249-258 ,1998.
Loffreda et al, “Leptin Regulates Proinflammatory Immune Responses”,The FASEB Journal,vol. 12, pp. 57-65, 1998.
Strobel et al, “A Leptin Missense Mutation Associated with Hypogonadism and Morbid Obesity”,Nature Genetics,vol. 18, pp. 213-215, 1998.
Giuffrida et al, “Isolation and Characterization of Full and Truncated Forms of Human Breast Carcinoma Protein BA46 from Human Milk Fat Globule Membranes”,Journal of Protein Chemistry,vol. 17, No. 2, pp. 143-148, 1998.
Hill et al, “Leptin: Its Pharmacokinetics and Tissue Distribution”,International Journal of Obesity,vol. 22, pp. 765-770, 1998.
Tartaglia et al, “Identification and Expression Cloning of a Leptin Receptor, OB-R”,Cell,vol. 83, pp. 1263-1271, 1995.
Cioffi et al, “Novel B219/OB Receptor Isoforms: Possible Role of Leptin in Hematopoiesis and Reproduction”,Nature Medicine,vol. 2, No. 5, pp. 585-589, 1996.
Clement et al, “A Mutation in the Human Leptin Receptor Gene Causes Obesity and Pituitary Dysfunction”,Nature,vol. 392, pp. 398-401, 1998.
Friedman et al, “Leptin and the Regulation of Body Weight in Mammals”,Nature,vol. 395. pp. 763-770, 1998.
Houseknecht et al, “Evidence for Leptin Binding to Proteins in Serum of Rodents and Humans: Modulation with Obesity”,Diabetes,vol. 45, pp. 1638-1643, 1996.
Murphy et al, “Long-term Correction of Obesity and Diabetes in Genetically Obese Mice by a Single Intramuscular Injection of Recombinant Adeno-Associated Virus Encoding Mouse Leptin”,Proc. Natl. Acad. Sci. USA,vol. 94, pp. 13921-13926, 1997.
Halaas et al, “Physiological Response to Long-term Peripheral and Central Leptin Infusion in Lean and Obese Mice”,Proc. Natl. Acad. Sci. USA,vol. 94, pp. 8878-8883, 1997.
Senaris et al, “Synthesis of Leptin in Human Placenta”,Rapid Communications,vol. 138, No. 10, pp. 4501-4504, 1997.
Considine et al, “Serum Immunoreactive-Leptin Concentrations in Normal-weight and Obese Humans”,The New England Journal of Medicine,pp. 292-325, 1996.
Marquez-ruiz et al, “Modification of Triacylglycerides and Apolipoprotein in Rats Fed Diets Containing Whole Milk, Skim Milk and Milk Proteins”,American Institute of Nutrition,pp. 1840-1846, 1992.
Levin et al, “Cell-Cell Interactions Promote Mammary Epithelial Cell Differentiation”,The Journal of Cell Biology,vol. 100, pp. 1415-1422, 1985.
Wiens et al, “Milk Protein Expression and Ductal Morphogenesis in the Mammary Gland in Vitro: Hormone-Dependent and Independent Phases of Adipocyte-Mammary Epithelial Cell Interaction”,Developmental Biology,vol. 120, pp. 245-258, 1987.
Rayner et al, “Postnatal Development of theobGene System: Elevated Leptin Levels in SuckIng fa/fa Rats”,Rapid Communication,pp. R446-R450, 1997.
Casabiell et al, “Presence of Leptin in Colostrum and/or Breast Milk from Lactating Mothers: A Potential Role in the Regulation of Neonatal Food Intake”,Journal of Clinical Endocrinology and Metabolism,vol. 82, No. 1, pp. 4270-4272, 1997.
Gainsford et al, “Leptin can Induce Proliferation, Differentaition, and Functional Activation of Hemopoietic Cells”Proct. Natl. Acad. Sci. USA,vol. 93, pp. 14564-14568, 1996.
Lord et al, “Leptin Modulates the T-cell Immune Response and Reverses Starvation-induced Immunosuppression”,Nature,vol. 394, pp. 897-901, 1998.
Lepercq et al, “Overexpression of Placental Leptin in Diabetic Pregnancy”,Diabetes,vol. 47, pp. 847-850, 1998.
Houseknecht et al, “Leptin is Present in Human Milk and is Related to Maternal Plasma Leptin Concentration and Adiposity”,Biochemical and Biophysical Research Communications,vol. 240, No. 3, pp. 742-747, 1997.
Flier, “Lowered Leptin Slims Immune Response”,Nature Medicine,vol. 4, No. 10, pp. 1124-1125, 1998.
Georgieff et al, “Mid-arm Curcumference/Head Circumference Ratios for Identification of Symptomatic LGA, AGA, and SGA Newborn Infants”,The Journal of Pediatrics,vol. 109, No. 2, pp. 316-321, 1986.
Patton et al, “A Method for Isolation of Milk Fat Globules”,Lipids,vol. 21, No. 2, pp. 170-175, 1986.
Trottier et al, “Increased Fat Intake During Lactation Modifies Hypothalamic-Pituitary-Adrenal Responsiveness in Developing Rat Pups: A Possible Role for Leptin”,Endocrinology,vol. 139, No. 9, pp. 3704-3711, 1998.
Chehab et al, “Early Onset of Reproductive Function in Normal Female Mice Treated with Leptin”,Science,vol. 275, pp. 88-90, 1997.
Zhang et al, “Positional Cloning of the Mouse Obese Gene and Its Human Homologue”,Nature,vol. 372, pp. 425-431, 1994.
Shimabukuro at al, “Direct Antidiabetic Effect of Leptin Through Triglyceride Depletion of Tissues”,Proc. Natl. Acad. Sci. USA,vol. 94, pp. 4637-4641, 1997.
Brooker et al, “The Epithelial Cells and Cell Fragments in Human Milk”Cell Tissue Res.,vol. 210, pp. 321-332,

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