Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-02-03
1993-07-20
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514419, 514423, 548469, 548492, 548493, 548494, 548503, 548504, 548509, A61K 3140, A61K 31405, C07D20918, C07D20942
Patent
active
052294137
ABSTRACT:
Compositions containing certain indole-2-carboxylate compounds and derivatives are described as being therapeutically effective in treatment of CNS disorders resulting from neurotoxic damage or neurodegenerative diseases, particularly those CNS disorders resulting from ischemic events. Preferred compounds are of the formula ##STR1## wherein each of R.sup.5 and R.sup.6 is independently selected from hydrido, bromo, chloro and fluoro, and wherein each of R.sup.10 and R.sup.12 is independently selected from hydrido and lower alkyl, and pharmaceutically-acceptable salts thereof.
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Cheng Brian K.
Cordi Alex A.
Dappen Michael S.
Gray Nancy M.
Hood William F.
G. D. Searle & Co.
Keane J. Timothy
Matukaitis Paul D.
Nutter Nathan M.
Smith Charles E.
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