Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-03-01
1992-08-11
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
424422, 424423, 424464, A01N 4338, A61K 3140, A61K 31405
Patent
active
051379104
ABSTRACT:
Compositions containing certain indole-2-carboxylate compounds and derivatives are described as being therapeutically effective in treatment of CNS disorders resulting from neurotoxic damage or neurodegenerative diseases, particularly those CNS disorders resulting from ischemic events. Preferred compounds are of the formula ##STR1## wherein each of R.sup.5 and R.sup.6 is independently selected from hydrido, bromo, chloro and fluoro, and wherein each of R.sup.10 and R.sup.12 is independently selected from hydrido and lower alkyl, and pharmaceutically-acceptable salts thereof.
REFERENCES:
patent: 4672074 (1987-06-01), Harendza et al.
patent: 4847283 (1989-07-01), Harendza et al.
Chemical Abstracts, 110:44972n (1989).
S. M. Rothman et al., Annals of Neurology 19 (2) (1986).
J. W. Johnson et al., Nature (London) 325, 529-531 (1987).
G. B. Watson et al., Neurosci. Res. Comm. 2 (3) 169-174 (1988).
I. A. Kemp et al., Proc. Natl. Acad. Sci. USA 85, 6547-6550 (1988).
A. C. Foster et al., Nature 338, 377-378 (1989).
M. Passerini et al., Gazz. Chim. Ital. 69, 658-664 (1939).
V. V. Feofilaktov et al., Zhur. Obshchei. Khim. 23, 644-656 (1953).
L. Kalb et al., Chem. Ber. 59B, 1860-1870 (1926).
R. W. Jackson et al., J. Am. Chem. Soc. 52, 5029-5035 (1930).
R. H. F. Manske et al., Can. J. Chem. 38, 620-621 (1960).
O. L. Hoffmann et al., J. Biol. Chem. 196, 437-441 (1952).
Cheng Brian K.
Cordi Alex A.
Dappen Michael S.
Gray Nancy M.
Hood William F.
Azpuru Carlos
C.D. Searle & Co.
Page Thurman K.
LandOfFree
Compositions containing indole-2-carboxylate compounds for treat does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions containing indole-2-carboxylate compounds for treat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions containing indole-2-carboxylate compounds for treat will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-346678