Compositions containing indole-2-carboxylate compounds for treat

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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424422, 424423, 424464, A01N 4338, A61K 3140, A61K 31405

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active

051379104

ABSTRACT:
Compositions containing certain indole-2-carboxylate compounds and derivatives are described as being therapeutically effective in treatment of CNS disorders resulting from neurotoxic damage or neurodegenerative diseases, particularly those CNS disorders resulting from ischemic events. Preferred compounds are of the formula ##STR1## wherein each of R.sup.5 and R.sup.6 is independently selected from hydrido, bromo, chloro and fluoro, and wherein each of R.sup.10 and R.sup.12 is independently selected from hydrido and lower alkyl, and pharmaceutically-acceptable salts thereof.

REFERENCES:
patent: 4672074 (1987-06-01), Harendza et al.
patent: 4847283 (1989-07-01), Harendza et al.
Chemical Abstracts, 110:44972n (1989).
S. M. Rothman et al., Annals of Neurology 19 (2) (1986).
J. W. Johnson et al., Nature (London) 325, 529-531 (1987).
G. B. Watson et al., Neurosci. Res. Comm. 2 (3) 169-174 (1988).
I. A. Kemp et al., Proc. Natl. Acad. Sci. USA 85, 6547-6550 (1988).
A. C. Foster et al., Nature 338, 377-378 (1989).
M. Passerini et al., Gazz. Chim. Ital. 69, 658-664 (1939).
V. V. Feofilaktov et al., Zhur. Obshchei. Khim. 23, 644-656 (1953).
L. Kalb et al., Chem. Ber. 59B, 1860-1870 (1926).
R. W. Jackson et al., J. Am. Chem. Soc. 52, 5029-5035 (1930).
R. H. F. Manske et al., Can. J. Chem. 38, 620-621 (1960).
O. L. Hoffmann et al., J. Biol. Chem. 196, 437-441 (1952).

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